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  June 14, 2024
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- Cone Starvation In Retinitis Pigmentosa
Progressive loss of vision associated with the disease Retinitis Pigmentosa (RP) is caused by cone cells starving from lack of nutrients and degrading their own parts.
- Seeing Cancer Specifics
Fluorescence probes capable of selective molecular imaging of living cancer cells are reported in a paper online.
- Bringing Galatea To Life?
Study shows that an inhibitor of the heterotopic ossification disease gene's protein product is partially therapeutic, and therefore offers hope for this devastating condition.
- Blood Stem Cells Require Editing
Researchers identify an essential enzyme needed to keep blood stem cells healthy.
- Reviving Exhausted Immune Cells
The way in which immune system exhaustion occurs and what steps can be taken to revitalize anti-viral immune responses is reported online.
- New Inherited Factors Influencing Blood Lipid Levels
Genetic variants that contribute to the different lipid levels and other metabolic traits that increase the risk of heart disease are reported in three papers published online.
- Melatonin And Risk Of Type 2 Diabetes
Variants in a gene encoding a receptor for melatonin that increase the risk of type 2 diabetes, are reported in three studies published online.
- Cancer Stem Cells And Melanoma
Research casts doubt on whether cancer stem cells alone encourage tumour development in melanoma, the most deadly form of skin cancer.
- Molecular Arms Race
A key immunity-related protein evolved quickly in a molecular 'arms race' with poxviruses.
- Binding Too Tight
An explanation for the link between a certain tissue type and coeliac disease is described.
- An enhanced tool for storage and mining of genome-wide expression data
A paper describes the latest version of an online tool for the storage and mining of genome-wide expression data
- New Anti-Inflammatory Arthritis Drugs
Researchers report a new class of anti-inflammatory drugs that stop the progression of collagen-induced arthritis in mice.
- Sticky Seizures
A possible link between epileptic seizures and an interaction between immune cells and brain blood vessels is reported.
- Predicting Vaccine Immunogenicity
Scientists reveal how the Yellow Fever virus vaccine triggers different immune responses.
- Spreading Brain Cancer
A simple blood test could be used to diagnose brain cancer.
- Inflammatory Mutation Found In Liver Cancer
A type of mutation that 'switches on' inflammatory signalling pathways in human liver tumours is described.
- Molecular Tug Of War Predicts Tamoxifen Response
A mechanism behind resistance to the anti-cancer drug tamoxifen in breast cancer is reported online.
- Cochaperones Help Determine The Fate Of Ricin Toxin
A balance between cochaperones that alter the functional activity of Hsc70 determine whether the cytotoxin is lethal or inactive after transport from the endoplasmic reticulum.
- A Window on Breast Cancer
Researchers have developed a technique to track individual breast cancer cells as they metastasize and invade other regions of the body.
- Souped-Up T Cells
Researchers have engineered killer T cells that are better able to limit the spread of HIV in cell culture.
- Making an Impact on Reproduction
The November 2008 issue of Nature Medicine reveals the papers that the reproduction community has chosen as the most important of the past three years.
- Fighting Neuroblastoma
A strategy to treat neuroblastoma using the patient's immune cells is published online.
- Neuronal Contribution to Risk of Multiple Sclerosis
The first risk variant for multiple sclerosis in a gene expressed specifically in neurons has been identified.
- Risk Variants for Intracranial Aneurysm
Scientists have identified two new genetic risk factors for intracranial aneurysm.
- Duplicitous Role for Classic Cancer Molecule
A molecule previously thought to promote cancer may in some circumstances play a part in slowing it down.
- Monkey Vaccine Fights Off AIDS
A study in monkeys demonstrates that T cells can be commandeered to provide protection against an HIV-like virus.
- Engineered DNA 'Scissors' Show Promise
A molecular 'pair of scissors' that snips out specific chunks of DNA has yielded promising results both in vitro and in cells.
- Cancer Genome Sequenced
An individual cancer genome has been sequenced for the first time, identifying mutated genes that probably have a role in the development of acute myeloid leukaemia.
- The Promise of Personal Genomics
The power of next-generation genome sequencing technology is demonstrated in two collaborations published.
- Widespread Alternative Splicing
Over 90% of human genes undergo alternative splicing, a form of messenger RNA processing that yields multiple proteins from a single gene.
- An enhanced tool for retrieval of known protein-protein interactions
A paper describes an online tool for the retrieval and visualization of known protein-protein interactions
- Excess Fatty Acid in Alzheimer's Disease
Correcting altered fatty acid metabolism in the brain of mice with Alzheimer's can reverse the cognitive deficits associated with the disease.
- Treating Lou Gehrig's Disease with Glial Stem Cells
Nerve cell degeneration in a mouse model of Lou Gehrig's disease can be slowed by transplantation of healthy glial cell precursors.
- Combating Muscle Fatigue
Researchers have identified a potential cause of fatigue in patients with neuromuscular diseases such as Duchenne muscular dystrophy.
- Mouse Brain Tumour Model Highlights Causative Role for Gene Duo
Two genes have been implicated in the development of a lethal brain tumour, highlighting potential targets for therapeutic development.
- Profiling Lung Cancer
By finding genes that are mutated in cancer cells compared with healthy cells, scientists are beginning to build a picture of what goes wrong to cause disease.
- Grow Your Own Prostate
Scientists have isolated single stem cells from the prostate and used them to generate new prostates in mice.
- Single Neuron Restores Activity
The activation of a single neuron in the brain may be enough to help restore muscle activity in the arms of paralysed patients with spinal cord injuries.
- A new tool for the screening of literature in genetic epidemiology
A paper describes a new online tool for the automatic survey of literature in genetic epidemiology
- How the Brain Helps Us Deal with Loss
Researchers have pinpointed a chemical messenger in the brain that plays a crucial role in dealing with the long term separation or loss of a partner.
- Linking Schizophrenia to Neuronal Changes
Alterations in neuronal development and connectivity may contribute to the psychiatric and cognitive symptoms seen in patients with a chromosomal mutation linked to schizophrenia.
- Nervous System Signals Direct Host Defence
Early host defence against pathogens -- at least in earthworms -- relies on communication between the nervous system and the intestine, suggests a paper online.
- New Risk Factors for Basal Cell Carcinoma
Two genetic variants associated with basal cell carcinoma (BCC) are identified online.
- Hair Follicle Stem Cells Identified
Scientists have discovered a group of stem cells in mice that can repopulate and maintain all cell types of the hair follicle.
- Susceptibility to Male-Pattern Baldness
New genetic risk factors for male-pattern baldness have been identified in two studies published online.
- Gene Mutation in Retinitis Pigmentosa
Scientists have found mutations in a gene that account for a significant number of cases of retinitis pigmentosa, a hereditary disorder of the retina that leads to visual impairment, and in some cases, blindness.
- The Genetic Origins of Cleft Lip
The first common genetic variant strongly associated with cleft lip has been identified in a study published online.
- Risk Factors for Ulcerative Colitis
Scientists have discovered genetic variants that predispose people to the common inflammatory bowel disease ulcerative colitis.
- Pluripotent Cells from Human Testis
Pluripotent adult stem cells have been derived from cells in adult human testis for the first time.
- Crick Hypothesis Vindicated
Two groups of brain cells together help to filter visual information before it reaches the brain's higher processing regions.

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