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  June 14, 2024
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- DNMT1: a direct transcriptional repressor?
Recent work shows an unexpected effect for a well known methyltranferase.
- Gene Therapy Alleviates Neurodegenerative Disease In Mice
Mice with neurodegenerative diseases have been successfully treated with gene therapy.
- Adapting Brain And Behaviour To Match The Environment
Zones in a specific brain area change size depending on whether rats experience a calm or stressful environment.
- Finding Allele-Specific Gene Expression
Scientists have developed a genome-wide technique to identify whether a person is expressing genetic information from their mother or father.
- Oncogenic microRNA
Scientists have discovered how a particular cluster of short strings of genetic material called microRNAs promotes lymphoma development.
- Damage Limitation
A key regulator of the DNA damage response is directly activated by the transcription factor FOXO3a - a protein known to regulate the cell cycle and cell death.
- 'Lifeline' For Tumour Cells Can Be Cut
Researchers studying cancers in mice have identified a protein that is crucial for tumour survival, raising the prospect that new cancer therapies might halt tumours in their tracks by targeting this molecule.
- Fresh Detective Approach Finds New Obesity Genes
By turning the conventional method of hunting for disease genes on its head, a team of geneticists has discovered three new genes linked to obesity.
- Missing Cells To Blame In Job's Syndrome
New research by immunologists on the rare immune disease called Job's syndrome shows that sufferers lack a specific type of white blood cell, leaving them open to repeated attack by certain bacterial and fungal pathogens.
- Subverting A Metabolic Pathway For Tumour Growth
Two research papers shed further light on the mechanisms underlying the switch in the way glucose is metabolized by tumour cells.
- 'Crime Boss' Gene Controls Aggressive Breast Tumours
Geneticists have identified a gene that promotes aggressive breast cancer by altering the behaviour of more than 1,000 other genes within tumour cells.
- New Insight into the Genetics of Brain Tumor Formation
Gene mutated in neural crest tumors normally helps promote apoptosis
- Role for MicroRNAs in Limb Regeneration
miRNA regulation in the model organism zebrafish impacts tissue regeneration
- Growing old together: Yeast, worms, and people may age by similar mechanisms
Genes conserved across evolutionarily diverse organisms may be important for human aging
- Household Allergens Make Skin Vulnerable To Eczema
Dust mite and cockroach allergens aggravate the symptoms of eczema and similar diseases by disrupting skin barrier function.
- Autoimmunity Affected By More Than A Defective Immune System
Research suggests that autoimmunity is linked to defective developmental biology as well as a defective immune system.
- Chemical Treatment Of Neurons Makes Them Light Sensitive
A chemical treatment that makes neurons light responsive is described.
- Bone Marrow Nurturers
Researchers have identified a new cell residing in bone marrow that provides an essential survival factor for antibody-producing B cells.
- Multi-Tasking Sensor Of Immune 'Danger'
Data explaining how a single sensor of 'danger' manages to activate two distinct host immune defense signaling pathways is presented.
- Mitochondrial DNA Deletions Affect Lifespan
Large DNA deletions in mitochondria are associated with premature ageing in mice
- Genetic Variants Predisposing To Coeliac Disease
Scientists have identified variants in seven genomic regions that predispose to coeliac disease.
- Pathway Influences Human Hair Growth And Texture
Researchers have identified the genetic basis of two related but clinically distinct forms of inherited hair loss.
- Altered Stem Cells Accelerate Ageing
Study provides a mechanism by which the mutant protein Progerin contributes to the premature ageing disease Hutchinson-Gilford Progeria Syndrome (HGPS), and implications for our understanding of normal ageing.
- Twist Mediates Hypoxia-Driven Tumour Metastasis
Study identifies a pathway that could be active in several types of cancer, and the importance of using certain protein inhibitors for tumour treatment.
- Drug Detective Kit For The Cell's Powerhouse
A large-scale analysis of the effects of almost 2,500 drugs and natural products on mitochondria promises to become invaluable to scientists seeking new ways to tackle diabetes, neurodegeneration and even ageing.
- Building A Picture Of Sight
A device that can 'read' the brain and produce a picture of a person's visual experience could soon become a reality.
- Turning Off 'Stemness' In Skin Cells
Researchers have discovered the switch mechanism responsible for imposing the molecular boundary between the proliferating basal cells and terminally differentiating outer skin cells.
- Targeting Psychosis
A pair of receptors in the brain that react to hallucinogenic drugs are identified as a potential target for the treatment of psychosis.
- Treatment-Resistant Depression Might Be In The Genes
Variation in the gene coding for the potassium channel TREK1 may explain why some patients with depression do not respond to commonly prescribed antidepressants.
- Reversing Impaired Brain Function In Diabetes
An increase in the stress hormone corticosterone that is caused by diabetes leads to deficits in the birth of new neurons and memory formation in rodents.
- DNA Proves Its Potential
The electrical conductivity of an individual DNA molecule can be measured by wiring it into a nanoscale circuit.
- How HIV Ravages Gut Immune Cells
The specific interaction between HIV and gut-associated immune cells, which may promote the depletion of cells and the virus' devastating attack on the immune system, is reported.
- New Syndrome Of Mental Retardation And Epilepsy Identified
A new syndrome characterized by mental retardation, epilepsy, and facial and digital abnormalities is associated with a small deletion on chromosome 15.
- Genome-Wide View Of Prostate Cancer Risk
At least ten newly identified genetic variants are associated with increased susceptibility to prostate cancer, according to three studies to be published online.
- Renewable Cell Therapy For Diabetes Inches Closer
Researchers have converted human embryonic stem (ES) cells into cells that release insulin in response to glucose and alleviate a diabetes-like condition in mice.
- BRCA2 And Resistance To Therapy
Scientists have gained new insight into how changes in BRCA2 can affect a cancer's resistance to therapy.
- Defining An Anti-HIV Protein
Understanding the structure of proteins involved in inhibiting HIV-1 infection could help in the battle against the disease.
- Sugars Regulate Insulin Signalling
An enzyme known to attach sugar to proteins in cells is revealed to have a role in insulin resistance in mice.
- Interpreting Our Past From Genomic Information
Two papers delve into the rapidly expanding databank to produce new nuggets of information to reconstruct our genetic history.
- Insight Into Brains Damaged By Multiple Sclerosis
An online paper describes an approach that homes in on two potential therapeutic targets for multiple sclerosis.
- Gene Variants Protect Against Depression
Corticotropin-releasing hormone receptor variants offer protection against adult depression following early-life stress.
- BMP signaling, skin stem cells & hair formation
A protein signal is crucial for hair production
- Tailoring Glioblastoma Therapies: One size does not fit all
Appropriate therapy is influenced by the tumor-causing genetic lesion
- Researchers identify a worldwide-distributed clone of bacteria responsible for Legionnaire’s disease
Genome analysis reveals distinctive traits found in pathogenic variants
- SARS Virus Entry Into Cells Involves Lipid Rafts
Lipid rafts have a key role when host cells are invaded by the SARS virus.
- Leukaemia Relapses Linked To DNA Repair Problems
Scientists have shown a link between acute myeloid leukaemia (AML), an aggressive cancer of the blood, and mutant genes in the DNA mismatch repair pathway.
- DNA Braces For Change
Dynamic DNA nanostructures can change their shape in response to specific molecular signals.
- Going Beyond p53's Role In Cancer
The tumour suppressor p53 has physiological roles beyond cancer.
- Natural Selection Shapes Modern Human Populations
Natural selection has influenced the morphological and disease-related diversity of modern human populations.
- Amyloid Inhibitors Are Aggregates Too
A new understanding of the way protein inhibitors work may have major implications in the development of drugs for Alzheimer's and other neurodegenerative diseases.

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