A key immunity-related protein evolved quickly in a molecular 'arms race' with poxviruses, a Nature paper suggests. It is thought that the strategy helps host stay ahead of pathogen.
Poxviruses, such as smallpox, produce a protein called K3L, which closely mimics the substrate of protein kinase R (PKR), an important component of vertebrate immunity. Nels Elde and colleagues show that PKR evolved under dramatic episodes of positive selection in primates, substituting amino acids at sites where K3L and PKR meet. The changes increase the probability of the host defeating the mimic and see the two protagonists locked in a molecular 'arms race', each trying to gain the upper hand.
In a related paper published online in Nature Structural & Molecular Biology, Stefan Rothenburg and colleagues provide evidence for poxvirus-driven evolution of PKR in vertebrates. They show that substituting a single amino acid in mouse PKR with the amino acid found at the same position in human PKR renders mouse PKR more resistant to K3L. The research demonstrates how an antiviral protein has evolved to avoid being deactivated by the virus, while maintaining its primary function.
Nels Elde (Fred Hutchinson Cancer Research Center, Seattle, WA, USA)
E-mail: email@example.com Author - Nature paper
Stefan Rothenburg (National Institute of Child Health and Human Development, Bethesda, MD, USA)
E-mail: firstname.lastname@example.org Author - NSMB paper
Abstracts available online:
Nature paper Abstract.
NSMB paper Abstract.
(C) Nature press release.
Message posted by: Trevor M. D'Souza
Bookmark and Share this page (what is this?)
Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.
Use the links below to share this article on the social bookmarking site of your choice.
Read more about social bookmarking at Wikipedia - Social Bookmarking