home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Nervous System Signals Direct Host Defence

  October, 16 2008 7:26
your information resource in human molecular genetics

Early host defence against pathogens -- at least in earthworms -- relies on communication between the nervous system and the intestine, suggests a paper online in Nature Immunology.

Previous studies conducted in other organisms indicated that signals from the nervous system can influence immune cells called lymphocytes, which act during later phases of immune responses.

Man-Wah Tan and Trupti Kawli now show that the worm nervous system is capable of modulating the very earliest, or innate, phase of the immune response against the human pathogen Pseudomonas aeruginosa. Cargo within vesicles released from the brain of worms infected with virulent -- or dangerous -- strains of this bacteria suppressed expression of anti-bacterial genes in intestinal cells. Avirulent -- or harmless -- strains of the bacteria did not trigger vesicle release, suggesting that bacteria targeted this system of brain-intestine communication to their advantage.

Whether these findings bear relevance to human host defence remains to be seen.

Author contact:

Man-Wah Tan (Stanford University, Stanford, CA, USA)
E-mail: mwtan@stanford.edu

Abstract available online.

(C) Nature Immunology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.