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  June 22, 2024
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- Gene Therapy For Carcinoma Of The Breast
Specific intervention by gene therapy is a possible alternative and complementary strategy for the treatment of breast cancer.
- Identification of a Model for Enhanced Pain Sensitivity
Low frequency stimulation of nociceptive C-fibers conditions spinal neurons to form a pain amplifier resembling the pathway underlying inflammatory hyperalgesia.
- The Sturge-Weber Foundation Announces Centers Of Excellence
This new initiative will promote the comprehensive care necessary for treating an individual who has a port wine stain (PWS), Sturge-Weber syndrome (SWS) or Klippel-Trenaunay (KT).
- The molecular cause of Leukaemia: A Tax-ing business
Scientists in Hong Kong believe they have uncovered the trigger for leukemia, a cancer of the blood that afflicts millions worldwide.
- Molecular Mechanism Of A Diabetes Vaccine Revealed
Heat shock protein 60 enhances CD4CD25 regulatory T cell function via innate TLR2 signaling.
- The Long And The Short Of It: Expanding Small RNA Biology In Mammals
Identification and characterization of two novel classes of small RNAs in the mouse germline
- European Biotech industry figures show signs of chronic under-funding
The latest figures published today compares biotechnology sectors across some eighteen European nations and the USA.
- Diabetic Neuropathy: Neurons zinc-fingered into life.
Loss of neuronal function due to diabetes is reversed in rats and humans using a novel gene therapy approach.
- Biogenerics and new technologies compete with 1st generation major protein products
The US$ 32 bln market of six major protein products is enfacing competition by less costly biogenerics and by improved products via drug delivery or protein engineering technologies and even oral, small molecule solutions
- Enzyme Mutations Might Lead to Tumor Formation
Lack of phosphodiesterase 11A (PDE11A, an enzyme that is involved in halting a cell’s response to hormones and stops cells from dividing is implicated in rare adrenal tumor development.
- SIV Vaccine Gives Hope for HIV Vaccine
Monkeys Vaccinated Against SIV Survive Longer After Infection
- Accurate Diagnosis by Gene Expression Profiling
For the first time, microscopically identical tumors from different patients are shown to be genetically distinct. This provides greater certainty about diagnosis and prognosis.
- Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism
A new neonatal diabetes syndrome associated with congenital hypothyroidism, congenital glaucoma, hepatic fibrosis and polycystic kidneys, is decribed.
- Mutations In CEP290, Which Encodes A Centrosomal Protein, Cause Pleiotropic Forms Of Joubert Syndrome
Mutations were identified in the CEP290 gene in five families with variable neurological, retinal and renal manifestations.
- How And When Should Genetic Tests For Cancer Be Used?
Two experts in the use of genetic testing call for primary-care physicians and oncologists to work with medical geneticists and genetic counsellors, to identify the best clinical course of action.
- New Techniques For Chromosomal Damage Control
Two articles describe tools for the detection of large-scale structural rearrangements in individual chromosomes.
- Urinary Tract Microbicide Prevents Infection
When bacteria enter the urinary tract, cells there secrete antimicrobial factors to thwart infection.
- Tumors That Suppress Immunity
Report shows how late-stage tumors can promote the development of 'suppressor' cells that prevent other immune cells from effectively fighting against the tumor.
- New Class Of Small RNAs Revealed
Two groups of researchers have unearthed a whole new class of small RNA molecules manufactured by the mammalian genome.
- Enzymes Make Their Mark
Members of a protein subfamily have been found to have demethylase activity.
- Virus Entry Proteins Visualized
Researchers reveal a fresh three-dimensional look at the spike proteins on HIV's coating that allow it to bind and fuse with human cells.
- Yellow Card For RNA Interference
Study shows that the long-term expression of RNA fragments in mice can end up killing the animals.
- Mechanism Links Protein Misfolding To Brain Disease
Researchers identify a chemical reaction that may lead to the formation of damaging protein clumps in the brain.
- Gene Therapy Prevents The Onset Of Diabetic Symptoms In Mice
Using state-of-the-art gene therapy techniques, University of Pittsburgh investigators have successfully prevented the onset of elevated blood sugar, or hyperglycemia, in diabetes-prone mice
- Vaccinia delivered CDA: the end for Ovarian Cancer?
University of Pittsburgh School of Medicine researchers have used gene therapy to either completely abolish or significantly inhibit tumor progression in a mouse model of ovarian cancer
- Study of a Vertebrate Genome Network During Embryogenesis
A study of the sea squirt Ciona intestinalis has yielded a four-dimensional map of genome regulation during development.
- Spotty mice flout Mendels Law
Scientists say they have demonstrated that animals can defy the laws of Mendelian inheritance. Researchers found that mice can pass on traits to their offspring even if the gene behind those traits is absent.
- Gaining more hen-sight into Lebers Congenital Amaurosis
University of Florida scientists have delivered a gene through an eggshell to give sight to a type of chicken normally born blind.
- Personalized Treatment Trial for Breast Cancer
Trial Designed to find the most effective approach to cancer treatment with the fewest side effects for women with early-stage breast cancer.
- In Elderly, The More Flu Vaccine The Better
U.S. Study Finds Higher Dose of Flu Vaccine Improves Immune Response in the Elderly
- Fluid Management Study in Lung Injury Shows Less Is More
Study Answers Long-Debated Questions on Fluid Management in Critical Care
- Inducible Regulation Of Runx2-Stimulated Osteogenesis
Researchers describe a retroviral system to deliver the Runx2 osteoblastic transcription factor.
- Mosaic Vectors For Efficient Vector Purification And Targeting To Vascular Endothelial Cells
Adeno-associated virus (AAV) 1 has shown the most promise among the AAV vectors for the transduction of vascular endothelial cells.
- RNAi Therapeutics: Can siRNAs Conquer SARS?
Report on a new approach to coping with emerging infectious diseases, that uses small interfering (si)RNAs.
- Regeneration Of Injured Optic Nerve
A treatment applied three days after optic nerve injury greatly improves regeneration.
- New Techniques For Chromosomal Damage Control
Two articles describe tools for the detection of large-scale structural rearrangements in individual chromosomes.
- Gene Variant Associated With Type 1 Diabetes
A new gene variant associated with risk of type 1 diabetes is reported.
- Mothballs Link Cell Death And Cancer
Components of the humble mothball are carcinogens because they block cell suicide.
- SUMO Switches Metastasis On And Off
New players in the process of metastasis of cancer cells are described.
- Immune Molecule Fuels Tumours
A molecule central to chronic autoimmune diseases also promotes the incidence and growth of tumours.
- Chromosome 1 Completes The Set
Report on the finished DNA sequence of human chromosome 1.
- Novel Antibiotic Fights Hospital Killers
Team of researchers discovers a potent natural antibiotic that kills many Gram-positive bacteria.
- A New Signal For Axon Regeneration Is Discovered
Oncomodulin, released from macrophages, stimulates axon regeneration as part of the response to optic nerve injury.
- The next generation of interferons needs improvement in efficacy and safety
The interferon alpha market is smaller than the interferon beta market, but is characterized by far more products and R&D projects.
- Tumor Stem Cells Turn Out to be Good Models for Brain Tumor Research
Glioblastoma tumor stem cell lines offer a powerful new tool for research and treatment.
- Prozac’s Target Revealed
Neural stem cells provide information about how cells become reactive to Prozac (fluoxetine).
- A Loose Fit May Be The Best Bet In Drug Design
Common wisdom challenged as loosely connecting ligands at receptor sites lead to better signalling.
- Total-Genome Analysis of BRCA1/2-Related Invasive Carcinomas of the Breast Identifies Tumor Stroma as Potential Landscaper for Neoplastic Initiation
Authors postulate that such a genetically unstable stroma might facilitate a microenvironment that may subsequently lead to neoplastic transformation.
- ELMOD2 Is A Candidate Gene For Familial Idiopathic Pulmonary Fibrosis
Research suggests ELMOD2 as a novel candidate gene for susceptibility in familial IPF.
- Human Genomic Deletions Mediated By Recombination Between Alu Elements
Scientists compare the reference human and chimpanzee genomes to determine the magnitude of this recombination process in the human lineage.

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