|
|
|
Scientists have isolated single stem cells from the prostate and used them to generate new prostates in mice. In a paper published online in Nature, Wei-Qiang Gao and colleagues describe the factors that make these cells identifiable, and show that they have long-term self-renewal.
The prostate shrinks and regenerates repeatedly in response to repeated cycles of androgen deprivation and production. A number of cell-surface markers have been reported to identify candidate prostate stem cells, but they are also markers for other stem cell types. The researchers identify CD117 as a marker of a rare adult mouse prostate stem-cell population, and use this marker in combination with others to isolate single cells that can generate a prostate on transplantation in vivo. CONTACT Wei-Qiang Gao (Genentech Inc, San Francisco, CA, USA)
E-mail: gao@gene.com Abstract available online. (C) Nature press release.
Message posted by: Trevor M. D'Souza
|
|
Variants Associated with Pediatric Allergic Disorder
Mutations in PHF6 Found in T-Cell Leukemia
Genetic Risk Variant for Urinary Bladder Cancer
Antibody Has Therapeutic Effect on Mice with ALS
Regulating P53 Activity in Cancer Cells
Anti-RNA Therapy Counters Breast Cancer Spread
Mitochondrial DNA Diversity
The Power of RNA Sequencing
‘Pro-Ageing' Therapy for Cancer?
Niche Genetics Influence Leukaemia
Molecular Biology: Clinical Promise for RNA Interference
Chemoprevention Cocktail for Colon Cancer
more news ...
|