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  June 14, 2024
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- Solving A Cancer Paradox - Why Ageing Cells Turn Into Tumours
Study shows that growth arrest in aging cells might directly lead to cell cancer formation.
- Stem Cell Switch
Study's findings suggest that p53 may protect the genetic stability of stem cells by inducing differentiation and subsequent cell death of defective stem cells.
- Red Blood Cell Boost
French researchers have come up with a method for producing red blood cells that may one day help overcome the shortage of donated blood.
- Neuroprotection Offered By Antibiotics
One team of researchers, focusing on the transporters that deal with glutamate, the principle excitatory neurotransmitter in the nervous system, explains how to produce more transporters for glutamate, and gives hope for preventing nerve failure.
- Insulin's Double-Edged Sword Explained
Study reveals that some cell switches are more sensitive to insulin than others, creating new possibilities for diabetes therapies.
- Gene Synthesis Gets Cheaper
A new method for synthesizing specific DNA sequences could revolutionize the production of genes in the laboratory.
- Molecule of the Year 2004
The Molecule of the Year 2004 is the imidazole-4-acetic acid- ribotide (IAA-RP).
- Small Variations in Genes Can Determine Risk of Developing Breast Cancer
Estrogen receptor genes and haplotypes associated with breast cancer risk
- Peptide Vaccine Can Produce Complete Remission in Myeloid Leukemia Patients
Vaccine made from the PR1 peptide, a small part of a protein found on the inside of leukemia cells.
- Stem cells of limited use for cardiac muscle repair
Transplanted hematopoietic stem cells demonstrate impaired sarcoglycan expression after engraftment into cardiac and skeletal muscle
- Research Shows Existing Diabetes Drugs May Kill Multiple Myeloma
Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands.
- Researchers discover new gene in colon cancer
15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-{beta}-induced suppressor of human gastrointestinal cancers.
- Gene vaccine for Alzheimer's disease shows promising results
Gene Vaccination to Bias the Immune Response to Amyloid-{beta} Peptide as Therapy for Alzheimer Disease
- Important Discovery of Gene Involved in Breast and Prostate Cancer
SEQUENOM's MassARRAY(R) System Identifies Variations in ICAM Genes Impacting the Most Common Cancers in Women and Men
- Protein Delivered Via Genetically Engineered Virus Slowed Glioblasoma Multiforme Growth
Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L)
- Gene Therapy Collaboration
Genzyme Corporation and Applied Genetic Technologies jointly develop novel therapeutics involving gene therapy.
- Novel Gene Transfer Prevents Hypertension-Related Enlarged Heart, Cardiac Fibrosis
Angiotensin II type 2 receptor gene transfer elicits cardioprotective effects in an angiotensin II infusion rat model of hypertension.
- International HapMap Consortium Widens Data Access
Mapping of Human Genetic Variation Will Speed Search for Disease Genes
- Genetic defect confers risk of major depression, resistance to SSRI drug therapy
Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression
- New antibiotic target could mean the end of pneumonia
Streptococcus pneumoniae Isoprenoid Biosynthesis Is Downregulated by Diphosphomevalonate
- A New Species Of Amyloid Peptide
Identification of a New Presenilin-dependent {zeta}-Cleavage Site within the Transmembrane Domain of Amyloid Precursor Protein
- A New Approach To ALS Treatment
A new treatment approach delays the progression of Amyotropic lateral sclerosis (ALS, often called Lou Gehrig's disease) in an animal model.
- Fluorescence Reveals Ubiquitination Dynamics
A new system for the in vivo tracking of protein ubiquitination states offers considerably more detailed kinetic information than earlier techniques.
- Promising Early Insight Into HIV Vaccine Research
A preliminary investigation of a therapeutic vaccine for HIV has shown some promising signs of efficacy in a subset of the treated patients.
- Killer Skin
Researchers report the identification of an antimicrobial protein secreted by the skin, called psoriasin, that preferentially kills the common gut bacterium Escherichia coli.
- Malaria Vaccine From GM Parasites
Large-scale production of an effective malaria vaccine may be possible in future.
- An Unexpected Regulatory Role For Seladin-1
A new component of the mammalian cellular defence mechanism against tumour production is identified.
- Common Blood And Immunity Precursor Cell Discovered
A new study gives the strongest proof yet for the existence of a common origin for both vascular cells and haematopoietic cells.
- Role Of Cancer Gene Identified
Study sheds light on the role of the BCL6 cancer gene.
- Mending A Broken Heart
Researchers have identified a molecule that they believe protects and promotes the survival of heart muscle cells.
- Genentech Named No. 1 Employer by Science Magazine
Top Employers Survey
- Life Science Innovation Dependent on Venture Capital, New Report Asserts
VC Investment in Biotech and Medical Device Companies Accelerates Time to Market, Extends and Improves the Lives of Millions
- Scientists Generate Human Islet Precursor Cells in Culture from Cadaveric Insulin-producing Cells
Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor Cells
- Improved Molecular Switch Could Serve as Sensor, Medical Tool
'Device' Made of Fused Protein Partners Is Shown to Be Reversible and Highly Sensitive
- Estrogen-Associated COX-2 Pathways Explain Protection From Heart Disease in Female Mice
Implications for Chronic Use of COX-2 Inhibitors in Pre-Menopausal Women
- Corautus Genetics Announces Publication of Gene Therapy Approach to Heart Disease in Circulation
Corautus' technology is currently being tested in a Phase IIb trial known as GENASIS ("Genetic Angiogenic Stimulation Investigational Study")
- New Protein “Stop Sign” Alters Blood Vessel Growth
Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins
- A Molecular Light Switch Silences Neurons
A technical report describes a new technique for rapid, reversible and precise silencing of neural activity that overcomes limitations of past techniques.
- How People Learn From Mistakes
A rare opportunity not only to record from single human brain cells, but also to study the effects of their loss suggests that a certain brain area may be important for our ability to form effective strategies.
- Busting Up Gallstones
A compound that alters the composition of the digestive fluid bile might prevent gallstone formation.
- West Nile Virus: Crossing Into The Brain
Researchers have discovered how West Nile virus enters the brain.
- Cancer Spreads
An Insight in the 18 Nov 2004 issue of Nature captures the excitement in the rapidly advancing field of cancer research.
- New Evidence For Cancer Stem Cells
An original study identifies brain tumour initiating cells and suggests them as new targets for more effective cancer therapies.
- Non-Coding RNA Helps To Regulate Insulin
New study provides hope for diabetes drug development by showing the power of a class of non-coding RNAs thought to regulate gene expression.
- Cutting Cholesterol With RNAi
Scientists report a simple and ground-breaking new way to use RNAi to cut cholesterol levels in mice.
- Nicotine Improves Survival In Sepsis
Research shows that acetylcholine is a physiological inhibitor of inflammation and suggest that molecules related to nicotine might be useful for the treatment of sepsis.
- Genetic Signature Of Female Promiscuity
First study to correlate mating behavior across a range of diverse species to changes in the sequence of a gene involved in reproduction.
- Human genome variation and 'race'
A special issue of the journal Nature Genetics, "Genetics for the Human Race", presents a comprehensive survey of what we currently know about the science of human genetic variation.
- Enzyme Baf60c Required For Heart Formation
Identification of a new molecule that regulates embryonic heart and muscle development in mice may suggest a new way that genes are controlled during organ formation, and provide a clue to how birth defects occur in humans.
- Reproductive Biology, Where Next?
A special section in the 04 Nov 2004 issue of Nature tackles some of the most pressing questions in the field of reproductive biology.

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