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  May 20, 2024
your information resource in human molecular genetics
- The Yin and Yang of Appetite Hormones
An analysis of the prohormone from which the appetite stimulant ghrelin is derived has uncovered a new appetite suppressant, dubbed obestatin.
- Cell-Specific Targeting of Nanoparticles
Through simple chemical modification of nanoparticles, it is possible to create disease-specific agents for diagnostic and/or therapeutic use.
- Genetic Analysis of Glioblastoma Brain Tumors Can Aid in Treatment Decisions
Customized cancer treatments promise better recoveries.
- Biorepository for Prostate Cancer
The U.S. National Cancer Institute to enhance the quality and availability of various biospecimens and associated data for the broader scientific community for prostate cancer studies.
- New research points to novel therapy for glaucoma
New research points to an active role for a tissue previously thought to be metabolically inert and highlights new targets for therapeutic intervention
- Retinal Neovascularization: More Veg, less VegF
Anti-VegF therapies dominate the field of retinal neovascular disease but a growing body of evidence suggest that vegetables are just as efficacious
- Common Viruses May Cause Cancer
Study implicates viral-mediated cell fusion as a possible engine of tumor formation
- Combination Microbicides Protect Monkeys Against HIV-Like Virus
Microbicides could potentially provide a safe, effective and practical way to prevent HIV transmission to women, especially in developing countries.
- Can We Coax the Immune System to Respond Better to Chemotherapy?
IL-2 administration along with chemotherapt and infusion of pre-chemotherapy lymphocytes boosts the immune system to fight cancer more effectively.
- Web Forum Launched for Schizophrenia Researchers
Forum to become a catalyst for creative thinking that will speed the pace of discovery
- How A Genetic Mutation Influences Schizophrenia
Two groups shed light on the linkage between a genetic mutation and the cognitive and physiological changes that may be involved in schizophrenia.
- Taking Away The Energy From T Cell Proliferation
A new class of immunosuppressive compounds is shown to block T lymphocyte proliferation by inhibiting lactate transport.
- Discovery Of A Context-Dependent Oncogene
The paradoxical behaviour of Krüppel-like Factor 4 (KLF4) - both a tumour-supressor or oncogenic, depending on the context - is explained.
- Magnetic Nanoparticles For Imaging Human Cell Transplants
Scientists have succeeded in using magnetic resonance imaging (MRI) to visualize therapeutic cells transplanted into patients.
- Embryonic Stem Cells Turned Into Elusive Endoderm
Researchers have turned human embryonic stem (hES) cells into a cell type found in human embryos that ultimately forms the pancreas, liver, lungs, and other organs.
- Microbicide Gel Protects Monkeys Against Simian HIV
A potential approach to preventing HIV infection in women is reported.
- Antagonizing Gene Expression
Study shows that a class of specially engineered compounds called 'antagomirs' can effectively silence the action of miRNAs in regulating gene expression.
- Mapping The Human Genome For Differences To Find The Genetic Causes For Disease
Researchers have mapped the most common genetic differences across the entire genome for 269 different humans in unprecedented detail.
- Non-Coding DNA Shows Adaptive Evolution
Paper provides evidence that the non-coding regions of the genome are actually under strong selection.
- Largest computational biology simulation mimics life's most essential nanomachine
Simulating movement of tRNA into the ribosome during decoding
- Fused Genes Can Trigger Development Of Prostate Cancer
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
- Flipped Genetic Sequences Illuminate Human Evolution And Disease
Discovery of human inversion polymorphisms by comparative analysis of human and chimpanzee DNA sequence assemblies
- Counting cytokinesis proteins globally and locally in fission yeast
Yale Researchers Make Cell Biology Quantitative
- Researchers Discover New Gene Regulation Mechanism
Messenger RNA "Cut and Run" scheme provides rapid stress response
- Expression Project For Oncology (expO) Collects 1,000th Malignant Tumor Specimen
Gene expression analysis with clinical information on hundreds of these specimens is now publicly available online
- Molecular drug pump may help reduce risk of Alzheimer's
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-b deposition in an Alzheimer's disease mouse model
- Hormone Might Cause Dangerous Pregnancy Complication
The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation
- Rett gene regulates alternative splicing
Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2
- Major Sequencing Progress
Solexa expects to be the first to deliver whole human genome sequencing at $100,000 per genome.
- New Method to Discover Gene Rearrangements
Promising for early detection for prostrate cancer.
- Teens with Deletion Syndrome Confirm Gene's Role in Psychosis
Further evidence for a gene involved in schizophrenia
- False or True?
There is increasing concern that most current published research findings are false.
- Clinical And Molecular Findings In Osteoporosis-Pseudoglioma Syndrome
The authors sequenced the coding exons of the low-density lipoprotein receptor related protein 5 (LRP5) in 37 probands suspected of having autosomal recessive osteoporosis-pseudoglioma syndrome (OPPG).
- High-Resolution Whole-Genome Association Study Of Parkinson Disease
The authors performed a two-tiered, whole-genome association study of Parkinson disease (PD).
- Children With IH And BWS Have Different Constitutional Epigenotypes Associated With Wilms Tumor
Study conducted on children with Wilms tumor and Idiopathic hemihypertrophy (IH), and Wilms tumor and Beckwith-Wiedemann syndrome (BWS).
- Nanocrystals Detect DNA
Fluorescent nanocrystals - also known as quantum dots - come in handy as DNA sensors.
- Maintaining Suppression
A pair of reports show that the regulatory T (Treg) cells require the immune modulator interleukin 2 (IL-2) for their maintenance and long-term function rather than for development, as previously thought.
- Development Of Immune Cells Associated With Allergy And Asthma
Two papers describe how one type of immune cell associated with allergic inflammation and autoimmunity ultimately causes disease.
- Malaria Protection -- Two Variants At Odds
Study shows that co-inheritance of two of the most common Malaria genetic variants, which individually confer protection, may cancel the protective effects.
- Stealing Hepatitis C's Raft
Scientists have found a new drug candidate that can be used to stop the liver-damaging Hepatitis C virus (HCV) from multiplying.
- Alzheimer's Disease - Understanding The Lipid Connection
Scientists report on the function of a mysterious protein, how it affects Alzheimer's and its link to cholesterol.
- New Methods To Derive Embryonic Stem Cells
Two papers published online now provide different means of deriving human embryonic stem cells, which involves embryo destruction, from mice without eliminating a cloned embryo that has the potential to develop.
- Abnormal Chromosome Numbers Produce Tumours
two papers provide new, more direct evidence to support The idea that a failure of proper cell division produces genomic instability and promotes the development of cancer.
- Small Molecule Inhibitor Of Cholera Discovered
Increasing antibiotic resistance requires the development of novel approaches to combating infection.
- Genetic Link To Tourette’s Syndrome
Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome.
- New Technique Adds Precision And Permanence To Gene Therapy
Complete and persistent phenotypic correction of phenylketonuria in mice.
- Faster Method To Create Antibodies For Disease Research
This new method is a simple way of creating libraries of specifically binding antibodies.
- Noise and Delays Explain Why Some Genes Oscillate in Activity
Delay-induced stochastic oscillations in gene regulation.
- Evolutionary Conservation Of A Mechanism Of Longevity From Worms To Mammals
Loss of mclk1 increases cellular fitness and lifespan in mice
- Fitting In
Newly Evolved Genes Adopt A Variety Of Strategies To Remain In The Gene Pool

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