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  June 14, 2024
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- Tumour Suppressor Linked To Heart Failure?
Inhibition of angiogenesis by the tumour suppressor protein p53 may have a critical role in the progression of cardiac hypertrophy to cardiac failure.
- New Role For Gut-Lining Cells?
Intestinal epithelial cells may have a key role in shaping the function of immune cells.
- Let-ting Cancer Develop
The microRNA let-7 regulates a gene frequently activated in human cancer
- Mouse Model of Spinal Muscular Atrophy Shows How To Extend Survival
Discovery of a truncated form of gene in spinal muscular atrophy leads the search for treatments for this untreatable disease.
- Influenza Virus Genomes Now Completed and Publicly Accessible
Two thousand influenza virus genomes have now been completed and are publicly available. This is information critical to developing treatments and vaccines.
- Reduced Brain Growth in Alcoholics with Family Drinking History
The brains of alcohol-dependent individuals are affected not only by their own heavy drinking, but also by genetic or environmental factors associated with their parents’ drinking.
- Experimental Vaccine Given During Pregnancy Reduces Stillbirths from Cytomegalovirus
An experimental vaccine has been developed that reduces stillbirths among rodents born to mothers infected with cytomegalovirus (CMV) — a common virus that can also cause mental retardation and hearing loss in newborn children.
- TOP Classes of Biologics with 2006 Sales of US$ 63.8 bln
Sales of the major cancer antibodies grew by 57 % to US$ 10.6 bln in 2006. Cancer antibodies are challenging the still no. 1 selling class of erythropoietins with 2006 sales of US$ 11.9 bln, but the lowest growth rate (6.4 %)
- Viral Highways: Spreading From Cell To Cell
A number of retroviruses, including HIV, induce cells to form long bridges along which the virus particles move from infected cells to uninfected cells.
- Splicing Out Of Control
A factor that regulates gene function by splicing messenger RNA may be involved in tumor formation.
- Abnormal Cell Migration
Mutations in a certain type of oncogene and tumor suppressor can collaborate to send cancerous cells into a malignant state.
- Sleep Deprivation Impairs Subsequent Learning
Sleep deprivation may impair the memory for subsequent experiences by altering the function of the hippocampus.
- A Method To Regrow Teeth
Scientists have for the first time successfully replaced natural teeth in mice with teeth that were created in a Petri dish from single cells.
- Making Room For Others
Newly activated antibody-producing immune cells can displace older antibody-synthesizing residents in the bone marrow.
- Consortium Tackles The Genetic Basis Of Autism
The genomes of the largest collection of families with multiple cases of autism ever assembled have been scanned in a new study.
- Large-Scale Survey Of Mutations In Cancer
One of the largest surveys of mutations in human cancers is reported online.
- Common Genetic Variant Protects Against Breast Cancer
Scientists have confirmed that a common genetic variant -- CASP8 -- offers modest protection against breast cancer,
- Human Adult Stem Cells Can Regenerate Muscle
Human adult stem cells isolated from human adult blood vessels are able to regenerate muscle in a mouse model of muscular dystrophy.
- HIV Reveals Vulnerable Side
Researchers view the crystal structure of a known broadly neutralizing human immunodeficiency virus (HIV-1) antibody as it binds to a specific part of HIV-1
- In utero Protein Regulation
A novel strategy for regulating a protein important in development is described.
- Genetic Indicators Of Type 2 Diabetes Risk
Geneticists have identified five different areas of DNA base-pair change that contribute significantly towards the risk of developing type 2 diabetes mellitus.
- 'Out Of Africa' With Helicobacter pylori
Scientists report that the key patterns in the distribution of H. pylori genetic diversity mirror those of its human host.
- Schizophrenic genes identified
A joint U.S.-Japanese study suggests gene mutations governing a key brain enzyme make people susceptible to schizophrenia.
- The market of recombinant coagulation factors is growing with next generation products
The growing market of recombinant coagulation factors posted 2006 sales of more than US$ 4.6 bln.
- Novartis maps genome of type-2 diabetes patients
Swiss pharmaceutical giant Novartis AG said it has mapped the genome of a large group of type-2 diabetes patients, enabling scientists to better search for the genes causing the disease.
- The Code of Codes: Scientists Discover Parallel Codes in Genes
The genetic code is nearly optimal for harboring information
- New Gene That Prevents Multiple Types of Cancer
CHD5, a protein that prevents cancer, seems to be a master switch for a tumor suppressive network.
- One Strike Out Eliminates Probable Tumor Suppressor
X-chromosome gene is strongly associated with a childhood cancer
- Clones Are Erased And Rebuilt
A cloned cell nucleus has its gene expression program wiped clean before being reprogrammed as an embryonic nucleus by the egg into which it has been transferred.
- Diagnosis And Treatment Insights For An Unusual Childhood Cancer Syndrome
An unusual case of a young girl with a colon cancer syndrome caused by recessive mutations in the mismatch repair gene MSH6 is described.
- Release Requirements
Report reveals how some viruses, such as HIV-1, must assemble and release themselves from infected host cells before invading neighboring, uninfected cells.
- Learning To Keep Newborn Neurons
Newly generated neurons are specially selected during the formation and recall of new memories.
- The Molecules Behind Angelman Syndrome
The molecular dysfunction underlying the neurological symptoms of Angelman syndrome (AS) is revealed.
- A Tool To Delete DNA
Study introduces a tool to rapidly delete regions of chromosome in mammalian cells including embryonic stem cells.
- A Mouse Shows Us How The Brain Works
A sensor that allows researchers to see signalling events between individual neurons may bring us a step closer to unravelling the mystery of how the brain processes information.
- Not Losing Sleep Over The Orexins
Study reveals a new method of promoting sleep by blocking a certain type of protein receptor.
- Dissecting Suppressor Cell Development
The development of a population of 'regulatory' immune cells is more complicated than originally thought.
- Sun Worshipers
Immune cells travel to protect the outer layers of the skin in response to sunlight-induced vitamin D.
- Annotating The Human Genome
A specific chemical signature of DNA sequences that promote the expression of nearby genes has been identified.
- New Form Of Bone Disorder Identified
Scientists have identified a new form of the bone disorder osteogenesis imperfecta, and have determined the genetic defect that underlies it.
- Potential New Therapeutic Target In Breast Cancer
Mice lacking a particular enzyme have a significant delay in developing mammary tumors, and less progression to secondary lung cancer.
- Receptor For New World Haemorrhagic Fever Viruses Found
Researchers have identified the receptor that gives New World haemorrhagic fever arenaviruses their entry point into mammalian cells.
- New Target For Parkinson's Disease
Results from a mouse study have highlighted a possible new target for treating Parkinson's disease.
- Continuous inactivation of tumor suppressors helps maintain tumors
Delicate balance of tumor suppressors and oncogenes shows that tumors may fight a constant battle with suppressors.
- Potential Preventative of Type 1 Diabetes in Oral Insulin
Clinical trial in which people at risk for developing Type 1 Diabetes take oral inslin to prevent the onset of the illness is currently being conducted.
- Overview On 2006 Sales Of TOP 20 Biologics To Be Released On February 26
A free compilation of the 2006 sales of the TOP 20 blockbuster and other major recombinant antibodies and proteins will be provided by La Merie Business Intelligence starting February 26
- Dosing convenience is mandatory to keep pace in the pipeline race of GLP-1 analogs for type 2 diabetes
The emerging market of GLP-1 analogs with 2006 sales of US$ 430.2 mln in the first full market year of twice-daily exenatide attracts other players in the diabetes field, but urges them to top exenatide by more convenient products
- Anticancer Activity Of An Adenoviral Vector Expressing Short Hairpin RNA Against BK Virus T-ag
Study indicates that siRNAs delivery via a viral vector have a potential usefulness as in vivo anticancer tool against viral and cellular oncogenes.
- Mapping Of Angiogenic Markers For Targeting Of Vectors To Tumor Vascular Endothelial Cells
Study shows that a single administration of the AdfVII/IgG1Fc vector destroys the peripheral but not the central vasculature of a tumor spheroid.
- Gene Therapy Targeting To Tumor Endothelium
In this review the authors assess the challenges faced and the vectors that may be suitable for gene delivery to exploit candidate targets.

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