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  July 16, 2024
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- Promoter Mutations That Increase Amyloid Precursor-Protein Expression Are Associated with Alzheimer Disease
The present study provides evidence that Amyloid Precursor-Protein (APP)-promoter mutations that significantly increase APP expression levels are associated with Alzheimer disease.
- Diabetes Gene At Root Of Wider Syndrome
Study shows that some of the 'Gain of function' gene mutations associated with neonatal diabetes mutations can cause a syndrome that can include developmental delay, epilepsy and muscle weakness.
- Old Drug, New Target
Scientists have identified a new target for an old drug that has been used to treat tuberculosis for over 50 years
- Better Digs Benefit Behavior: New Neurons Not Required
A new study fails to find a causal relationship between behavioral improvements and increased neurogenesis in adult mice.
- Sensing Bacterial Infection
New information on the complex interplay between host cells and bacteria during infection is reported.
- Common Genetic Variant Associated With Prostate Cancer
A common genetic marker that is found more frequently in men with prostate cancer than those without is reported in a study.
- Nuclear Protein Controls Virus Invasion
A protein in the cell's nuclear membrane regulates the ability of the HIV virus to invade human cells.
- Parkinson's Gene Cripples Mitochondria
Two teams of scientists reveal that a mutant protein implicated in inherited Parkinson's disease disables the cell's mitochondria.
- LOX Stops The Spread
Scientists identify a protein vital for metastasis that could be a new target for cancer therapies.
- Not Without Risk
A gene-therapy treatment for a severe immune deficiency could contribute to the later development of T-cell lymphomas.
- Creation of Targeted Nanoparticles
Multifunctional nanoparticles, formed via polymerization, offer a new approach to delivering anticancer drugs with a high degree of specificity.
- Algorithm Enhances Ability To Detect Cancer Genes
Mapping Tumor Suppressor Genes using Multipoint Statistics from Copy-Number Variation Data
- Stomach Receptor For H. Pylori Discovered
Decay-accelerating Factor (DAF) acts as a Receptor for Helicobacter pylori and a Mediator of Gastric Inflammation
- Feinstein Researchers Identify Intelligence Gene
Genetic variation in DTNBP1 influences general cognitive ability
- RNA interference (RNAi) is coming of age as a therapeutic modality
With four clinical stage projects and 14 projects approaching IND status within the next year, RNAi is evolving as a new therapeutic modality.
- The bald truth in the genes
Combing of the genes to help prevent cancer, researchers suggest a particular gene may have some fringe benefit.
- New Medication To Help Treat Alcohol Dependence
The medicine, Naltrexone was shown to be just as effective specialized counseling for alcohol dependence when delivered with medical management.
- Anthrax Toxin Inhibitor Designed
Technique May Also be Applicable to Other Disease Toxins
- Genetic Link Between Eczema, Psoriasis, Asthma, and Hay Fever
Just the right balance of connexin 26 is required to keep skin and mucosal barriers from causing immune reactions.
- A Text-Mining Analysis Of The Human Phenome
Scientists have used text mining to classify over 5000 human phenotypes contained in the Online Mendelian Inheritance in Man database.
- Schizophrenia Genetics: Uncovering Positional Candidate Genes
Reports outlines the evidence supporting each of the proposed positional candidate genes.
- A Novel Mutation In JARID1C Gene Associated With Mental Retardation
Report presents results obtained by screening the JARID1C gene in 24 mentally retarded males with history of at least two affected males.
- Neural Effects Of Cocaine Withdrawal
Scientists describe a mechanism in the brain that may contribute to the cue-triggered drug seeking during abstinence.
- Teaching Transplant Tolerance
Study explains how specific immune cells help to make transplanted donor tissue 'tolerable'.
- Natural Memory
Natural killer (NK) cells, an important component of the immune system, can 'remember' prior exposure to foreign molecules.
- Genome Wide Profiling Of Chromatin Elements
A new study reports the binding profile of proteins involved in organizing the structure of DNA in the Drosophila genome.
- New Link To Insulin Sensitization
A new component involved in the regulation of an adipose-tissue hormone linked to insulin action.
- Better Detection To Tackle Bioterrorism
Scientists have developed a test that is at least a thousand times more sensitive than the best current approaches for detecting in the field trace quantities of cholera and botulinum toxins.
- Stem Cells And Leukaemia
Study shows that a signalling molecule known as phosphatase and tensin homologue, or PTEN,is crucial in keeping in balance the normal expansion of cell numbers in the bone marrow proliferation pathway.
- Regular Recycling Saves Lives
Two research papers suggest that the process of protein degradation and clearance of cellular components may be more important in maintaining the nervous system and keeping neurodegeneration at bay than was previously understood.
- Keeping Stem Cells In Check
A group of proteins has been shown to help hold the reins on embryonic stem (ES) cell differentiation.
- Metabolic Phenotype Predicts Drug Response
European team proposes a new way to personalize drug therapy based on a patient's metabolic phenotype.
- Evading The Immune System To Deliver Viral Antibodies
A virus that shows promise as a means of vaccine delivery of HIV-1 antigens could be altered to become effective in a larger portion of the population.
- Triggering Insulin Resistance
Study identifies reactive oxygen species as key players in the development of insulin resistance.
- Identifying The Function Of p110-alpha AOP
One form of the enzyme p110-alpha PI(3)K is vital for cell growth and metabolism.
- A Matter Of Taste
An identical variability in taste sensitivity evolved independently in chimpanzees and humans.
- Minimal Cocktail For Growing Human Embryonic Stem Cells Established
hESC cocktail contains only purified recombinant, chemically-synthesized, or purified human factors to support the cell growth
- Gene Variant Protects Against Type 2 Diabetes, Heart Disease, And Hypertriglyceridemia
Identification of variant indicates that aP2 might play a similar role in humans as it does in mice
- Study Holds Promise For A New Approach To Drug Therapy
Differential targeting of Gbetagamma-subunit signaling with small molecules
- New Mechanism for Essential Genome-Wide Gene Silencing Identified
Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications
- Blood Pressure Medication May Revolutionize Treatment Of Marfan Syndrome
Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
- Polycomb Regulation of Embryonic Stem Cell Differentiation
Polycomb group proteins play a key role in regulating vertebrate embryogenesis and in maintaining stem cell pluripotency.
- Apes and ApoB: systemic silencing
RNAi steps closer to a clinically relevent therapy with positive outcomes in a non-human primate study via systemic delivery.
- Drug addiction: a hit from the genes
Yale School of Medicine researchers have identified a genetic linkage for dependence on drugs such as heroin, morphine and oxycontin.
- Switching: a light on gene regulation
Scientists have released a map of regions in the human genome that work as switches for gene regulation.
- Combination Therapy Improves Rheumatoid Arthritis Symptoms
A rheumatologist proposes an improved treatment policy for people with early rheumatoid arthritis.
- Gene Therapy Rescues Immunodeficiency
Paper reports clinical improvement on two adults who received gene therapy for the treatment of X-linked chronic granulomatous disease (X-CGD).
- Memories Of A Naïve Killer
Efficient generation of immune cell memory can arise even in the absence of prior immunization or immunologic experience.
- Immune Traffic Express Lane
A new traffic route for immune cells along the body's highways is presented.
- Mitochondrial DNA Role In Aging And Parkinson Disease
Two new studies present evidence associating damage to mitochondrial DNA with aging and Parkinson disease.

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