| 2003-05-01 |
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Ovarian Cancer Cells Can Alter Surroundings to Promote Self-Preservation
Collagen VI appears to help ovarian cancer cells alter their microenvironment so they are more resistant to chemotherapeutic drugs
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Sloppy Repair Helps Tuberculosis Bug Resist Drugs
Shoddy work by a DNA-repair enzyme allows tuberculosis-causing bacteria to develop antibiotic resistance
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Anthrax Genome Decoded
The complete sequence of the 5.2 million base pairs of the DNA in B. anthracis' single chromosome is published
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Gene Discovery Opens Door to Further Research In Inherited Neurological Disorders
Charcot-Marie-Tooth and Distal Spinal Muscular Atrophy Gene May Shed Light on Carpel Tunnel Syndrome and Lou Gehrig's Disease
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| 2003-04-21 |
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Young Neurons In Old Brains
The functional properties of adult-born neurons develop in a different order than that seen in young animals.
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Organ Alchemy: Producing Insulin In The Liver
Introducing pancreatic genes into cells in the adult liver directs those cells to produce insulin and reverses diabetes in a mouse model of the disease.
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Lost Genes Lend New Strength To TB Vaccine
Reinforcing the existing tuberculosis (TB) vaccine with new genes from the microbe that causes the disease makes the vaccine more effective.
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Smart Bone Repair
'Smart' material may eventually be useful for healing injured bone or other tissues in human patients.
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Suicidal Gene Therapy Fights Hepatitis C
Scientists demonstrate that adenoviral gene therapy can lead to significant reductions in levels of hepatitis C virus in mice containing virally infected human liver cells.
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Stem Cell Injections Improve Paralysis In Mouse Model Of Multiple Sclerosis
Researchers hope that, in future, similar therapies will be used to treat human MS and other autoimmune diseases.
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Understanding How Blood Is Made
A key gene involved in the production and growth of blood stem cells, Bmi-1, regulates the activity of normal and cancerous blood stem cells.
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| 2003-04-07 |
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Transplanted Organs Bear Perilous Passengers
Tumor cells hidden in a transplanted organ can cause Kaposi sarcoma (KS) in the organ recipient.
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Dysfunctional Gene Dooms Ovarian Tumors
Small alterations in a gene required for responding to chemotherapy can result in drug-resistant ovarian cancer.
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Target And Switch
Two studies explain how immunoglobulin genes are uniquely identified to switch and why other genes aren't accidentally mangled.
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p53 Ways To Kill A Cell
The phosphatase PAC1 is necessary and sufficient to induce p53-dependent cell death.
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Biology's Own 'Department Of Homeland Security'
Structures of the human enzyme hCE1 suggest how hCE1 is able to bind to a wide range of substrates (drugs and chemical warfare agents).
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Cancer Stems From Early Stem Cells
Mathematical model suggests that some late-life cancers may be due to defects occurring in early development.
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| 2003-04-06 |
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NCI Study Estimates More Than 2 Million Women Could Benefit From Tamoxifen
Tamoxifen chemoprevention for women in the United States
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Hydroxyurea Therapy Improves Survival in Most Severely Affected Sickle Cell Patients
Sickle cell anemia patients who took the drug hydroxyurea over a 9-year period experienced a 40 percent reduction in deaths.
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Accident in Animal Lab Raises Questions About a Chemical Used in Some Plastics
A sudden increase in chromosome abnormalities in a mouse colony has raised questions about the safe level of exposure for bisphenol A.
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| 2003-03-31 |
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Solving A Parkinson Disease Side Effect
The study suggests that using other drugs to counteract an unwanted effect of L-DOPA may be a promising way to improve treatment of the disease.
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It Takes Two To Build Blood Vessels
Using the right combination of molecules is the key to creating stable blood vessels, and will be an important consideration when designing angiogenic therapies.
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A Direct Hit On Parkinson Disease
Injecting a naturally occurring molecule directly into the brains of Parkinson disease patients may help alleviate their symptoms.
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Keeping Hematopoietic Stem Cells Young
The discovery of a newly identified protein provides a ‘missing link’ in the long search for the exact conditions that allow blood stem cells to flourish.
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Mutations Of The X-Linked Genes Encoding Neuroligins NLGN3 And NLGN4 Are Associated With Autism
A defect in two X-linked genes may abolish formation, stabilization or recognition of specific synapses essential for the communication processes that are deficient in individuals with autistic spectrum disorder.
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Stem Cell Fusion Repairs Damaged Liver
Transplanted stem cells may repair liver damage by fusing with host cells.
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Spanish "Talking Glossary of Genetics" Launched Online
A resource for Spanish-speaking people seeking a better understanding of recent advances in genetics and genomics
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HHS To Test Use Of Handheld Device Network For Transmitting Urgent Information About Biological Agents To Clinicians
Bioterrorist possibility causes US Health and Human Services to use PDAs in communicating urgent information
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Metastasis Gene May Be Useful for Diagnosis and Treatment of Liver Cancer
The gene for osteopontin may be a useful diagnostic marker for metastasis
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| 2003-03-24 |
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Healthy-On-Arrival Lung Transplants
Researchers have found a way of increasing the efficiency of lung transplantation by protecting donor tissues.
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Lining Repair Signals Identified
Study describes mechanism which allows epithelial cells to stand poised to promote their own healing.
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None Today, Hair Tomorrow
Three steps are needed to turn skin stem cells into hair follicles, rather than other cell types.
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Test Reveals Obesity Subtypes
Study suggests that obesity may not be one disease, but a collection of conditions, each with its own genetic identity.
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HIV's Sweet Revenge
An ever-evolving sugar shield may thus help HIV-1 to escape the immune system.
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| 2003-03-22 |
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SARS and some preliminary histology
SARS
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| 2003-03-17 |
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Recently published - Nature Genetics Ten-Year Retrospective (1992-2002)
This special supplement reviews the scientific advances of the last ten years - and provides some insight into what lies ahead.
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Mutation Causes Motor Neuron Disease
The findings could help hone in on the causes of related diseases.
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Safer Magic Bullets
Researchers have found a way that could potentially avoid the debilitating side effects seen in patients taking a type of experimental cancer therapy.
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Insulin Regulation
New insights into how glucose homeostasis is achieved.
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Mouse Model Provides Clues Into Effects Of Nerve Gas
Compounds used as chemical warfare agents induce neurological damage by hampering the action of a specific enzyme.
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Autopsy Exposes Adverse Effects Of Alzheimer's Vaccine
Scientists present the first analysis of the vaccine's effects on the human brain.
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Nature Publishing Group Announces The Launch Of The Signaling Gateway
A new one-stop FREE resource for cell signaling research from the Alliance for Cellular Signaling (AfCS) and Nature Publishing Group (NPG).
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| 2003-03-09 |
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Protein Structure Initiative Center Maps Protein Universe
Protein shapes that nature repeats over and over again constructs the billions of complex proteins that make up life
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Cowabunga! Scientists to Start Bovine Genome Project
US NHGRI Approves Cow Sequencing; Launch Contingent on Funding
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Alcohol Researchers Relate a Genetic Factor to Anxiety in Women
The culprit is the catechol-O-methyltranferase gene, or COMT, a major enzyme responsible for the metabolism of certain neurotransmitters
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| 2003-03-03 |
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Antibody-Producing Cells Need Stress
Research produces new clues about how diseases, such as multiple myeloma, arise and may lead to new therapeutic targets.
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| 2003-02-28 |
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Gene that Determines Major Sensitivity to Bitter Taste
Gene to distinguish a wide class of bitter tastes found
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Genetic Basis of Pain Response
A common genetic variant influences individual responses and adaptation to pain and other stressful stimuli
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Adult Stem Cell: Possible New Indicator of Heart Disease Risk
Endothelial progenitor cells may help the body repair damage to blood vessels
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| 2003-02-24 |
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Alzheimer’s Disease Peptide Acts At A Distance
Beta amyloid peptide outside cells, rather than within neurons, may be the type that is detrimental in Alzheimer's disease.
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