home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Linking Schizophrenia to Neuronal Changes

 
  October, 16 2008 8:19
your information resource in human molecular genetics
 
     

Alterations in neuronal development and connectivity may contribute to the psychiatric and cognitive symptoms seen in patients with a chromosomal mutation linked to schizophrenia. A study published online in Nature Neuroscience now provides some clues to understanding the neuronal consequences of these mutations.

12% of schizophrenia cases in Caucasian populations are associated with small deletions in chromosome 22. About 30% of people with a particular microdeletion in this chromosome develop schizophrenia and many of them also have cognitive deficits.

Maria Karayiorgou and colleagues recreated this microdeletion in mice and studied neurons from the hippocampus. They report that the neurons carrying the microdeletion show reduced numbers of neuronal contacts and stunted dendrite growth. They also link these deficits to the loss of a specific enzyme that is lost with the microdeletion. This enzyme is responsible for adding fatty acid groups to certain proteins.

These findings point to alterations in neuronal proteins (specifically, a particular process called palmitoylation) as important contributors to the disease.

Author contact:

Maria Karayiorgou (Columbia University, New York, NY, USA)
E-mail: mk2758@columbia.edu

Abstract available online.

(C) Nature Neuroscience press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.