home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Risk Variants for Intracranial Aneurysm

  November, 14 2008 5:09
your information resource in human molecular genetics

Scientists have identified two new genetic risk factors for intracranial aneurysm according to a study published online in Nature Genetics.

An intracranial aneurysm is a dilation of a blood vessel in the brain, which can lead to haemorrhage and stroke, the latter being the world's third leading cause of death. Richard Lifton and colleagues carried out a genome-wide association study of over 2,100 Finnish, Dutch and Japanese individuals who had such an aneurysm, as well as 8,000 controls. They identified three variants associated with increased risk, including variants on chromosomes 2 and 8 that are newly implicated.

The most likely candidate to explain the risk associated with the variant on chromosome 8 is the gene SOX17, which is known to be required for formation and maintenance of endothelial cells, which line blood vessels. SOX17 also has a role in the generation of stem cells that give rise to blood cell and endothelial lineages, and the authors suggest that intracranial aneurysm may result from defective stem cell-mediated vascular development and/or repair.

Author contact:

Richard Lifton (Yale University School of Medicine, New Haven, CT, USA)
E-mail: richard.lifton@yale.edu

Abstract available online.

(C) Nature Genetics press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.