home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Souped-Up T Cells

  November, 14 2008 5:44
your information resource in human molecular genetics

Researchers have engineered killer T cells that are better able to limit the spread of HIV in cell culture. The study published this week in Nature Medicine finds that the enhanced cells can also recognise virus that has mutated to try and escape this response.

T cells are alerted to the presence of HIV by the T-cell receptor (TCR), which recognises fragments of virus proteins displayed as warning flags on the surface of infected cells. Current methods to isolate specific T cells that recognise HIV rely on cloning cells from HIV patients - a slow and painstaking process - and often these cells have TCRs that only weakly detect virus-infected cells. The virus can also mutate to avoid being detected.

James Riley and colleagues used 'phage display' technology to isolate a TCR from T cells from an HIV infected patient, which identified a fragment of the virus particularly well. The team then engineered the TCR to be much better at finding the virus. Putting this TCR into T cells created killer cells that were better at restricting the spread of HIV in cell culture. It remains to be seen whether these T cells can control virus infection in animals or patients and therefore become a practical form of therapy.

Author contact:

James Riley (University of Pennsylvania, Philadelphia, PA, USA)
E-mail: rileyj@exchange.upenn.edu

Abstract available online.

(C) Nature Medicine press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.