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  May 24, 2024
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- Stress May Increase Teen Risk for Smoking
Neurobiological factors and stressful life events can trigger and prolong smoking habits in adolescents, especially in individuals with depression.
- Silence, Please!
A new formulation of magnetic nanoparticles used to deliver nucleic acids that slow tumour progression in mice is reported online.
- Fighting Fibrosis
A potential new target for drugs aiming to treat lung fibrosis is reported.
- Misbehaved Bacteria
Some bacteria in the intestinal flora can cause colon cancer, and a study discloses a molecular mechanism for this undesirable effect.
- Cilia's Dual Role in Cancer
Cilia can promote or suppress tumor growth, depending on the nature of the tumor-initiating event.
- Fighting Cartilage Loss in Osteoarthritis
The identification of a new potential therapeutic target against osteoarthritis is reported.
- Mediator Of Multiple Sclerosis
A factor that may contribute to the progressive phase of multiple sclerosis (MS) has been identified.
- Genetic Risk Factors for Childhood Leukemia
Common genetic variants associated with pediatric acute lymphoblastic leukemia (ALL) have been identified in two new reports published online.
- Preventing Diseases by Replacing Defective DNA
A new approach has been devised to replace defective mitochondrial DNA (mtDNA) from an egg with healthy mtDNA from a donor.
- Antioxidants Reveal a Darker Side
The cancer-preventing reputation of antioxidants takes a hit with the discovery that they can sometimes promote the survival and proliferation of cancer cells.
- A Model for Drug Screening
Stem cells have been induced from patients with an extremely rare neurological disorder and their particular gene expression examined.
- Identifying Candidate Genes by Targeted Sequencing
A sequencing method that targets only the protein-coding regions of the genome could be used to identify rare and novel disease-causing gene variants.
- Hope for Hepatitis C Treatment
DNA sequence variation that affects a person's response to treatment for chronic infections by the hepatitis C virus is reported online.
- Tools for conversion of IDs in genomics
A list of freely available in silico tools for conversion of IDs in human genomics is presented
- Antibodies for Strep Throat Linked to OCD in Mice
A study in mice gives support to a suspected form of pediatric obsessive-compulsive disorder (OCD) thought to arise from an inappropriate immune response to common throat bacteria.
- Recovering Movement after Spinal Cord Injury In Rats
Forepaw function in rats with severe spinal cord injury can be substantially improved through a combination of specialized exercises and treatment with specific proteins.
- How Marijuana Causes Memory Deficits
Memory loss associated with marijuana use is caused by the drug's interference with the brain's natural protein synthesis machinery.
- Recovery after Spinal Cord Injury
Anatomical reconnection of severed nerves is possible in a rat model of spinal cord injury.
- Inhibiting Lymphatic Vessel Growth
The discovery of the first endogenous inhibitor of lymphatic vessel growth is reported.
- Immune Cells Worsen Brain Damage after Stroke
A class of immune cells has been implicated that have a harmful role in the late phase of ischemic brain injury.
- A New Progenitor Cell Population in Breast Cancer
Published study indicates that luminal cells that line the mammary ducts may also be tumor progenitors.
- From Gorilla to Human: A New Immunodeficiency Virus Found
The existence of a new human immunodeficiency virus (HIV) derived from gorillas is reported.
- Instigator of Type 1 Diabetes?
Alterations in the activity of the Deaf1 protein may influence the onset of type 1 diabetes.
- 'Trojan Horse' Deliveries by HIV
A report published online sheds light on the processes that allow HIV to disrupt the immune system.
- Mutations in Rare Human Diseases
Mutations in the INPP5E gene lead to defects in the primary cilium-a microscopic antenna-like structure that protrudes from almost every cell in the mammalian body.
- New Genetic Variants Associated with Cancer
Common gene variants are associated with increased risk of 3 different types of cancer.
- Single-Instrument Human Genome Sequencing
The complete genetic makeup of a person has been determined using only a single DNA sequencing machine.
- p53 as a Barrier to Pluripotency
The well known molecule p53 serves not only as a tumour suppressor, but also acts as a barrier to the generation of induced pluripotent stem (iPS) cells.
- Mice Generated from Reprogrammed Cells
Research team reports the generation of fertile adult mice derived entirely from induced pluripotent stem (iPS) cells.
- BioMart: Retrieval and mining of genomic data in an easy way
BioMart is a freely available online tool for retrieval and mining of genomic data
- Exploring Exploration
Scientists show that a gene regulating dopamine breakdown is predictive of how likely people are to explore alternative strategies when uncertain about current strategy.
- The Immunology of Obesity
The potential mechanism by which chronic, mild inflammation of fat tissue in obese patients promotes the onset of diabetes, is reported in a series of studies published online.
- Why Did the HIV Vaccine STEP Trial Fail?
Two papers rule out a leading explanation for the failure of the recent HIV STEP trial which represented a serious blow to the development of an AIDS vaccine.
- Cell Source Matters for In Vitro Bone Growth
The type of cell used to grow bone for tissue replacement in the lab makes a difference to the properties of the resulting material.
- Suppressor Immune Cells: Friends or Foes?
Regulatory T (Treg) cells, which are essential to prevent catastrophic autoimmunity in mice and humans, can in some cases convert into inflammatory T cells capable of exacerbating autoimmunity.
- A Genetic Susceptibility Locus for Follicular Lymphoma
A common genetic variant is associated with risk for follicular lymphoma (FL).
- Chromosomes, Know Your Place
A catalogue of factors that help to keep the order of genes on chromosomes 'in their place' and so prevent genomic instability is revealed.
- Alzheimer's Gene Linked to Neurotransmitter Release
A gene best known for its link to Alzheimer's disease is now shown to be essential for regulating neurotransmitter release.
- Looking for Clues to Extending Life
Scientists discuss recent progress in mammalian sirtuin research and what role these enzymes may have in age-related diseases and how long we live.
- Live Mice from Fibroblast
Stem cells induced from somatic cells can be as pluripotent as stem cells extracted from embryos.
- New Function for Classic Tumour Suppressor Protein
The tumour suppressor protein p53 may have a previously unappreciated role in the processing of miRNAs.
- Possible Mechanism for Blood Cancer Type
A new molecular mechanism may underlie a diverse group of blood cancers called myelodysplastic syndromes.
- MDR: A program for identification of gene-gene interactions
MDR is a freely available program for the identification of gene-gene interactions
- Neural Changes Mediating Addiction and Relapse
A study published sheds some light on the neural mechanisms that explain the transition from recreational drug to compulsive abuse and relapse.
- Action Representation in the Autistic Brain
Children with autism rely more on internal cues about the orientation of their limbs when learning to use a novel tool in new situations, reports a study.
- New Player in T Cell Maturation
Three papers show that a previously uncharacterized protein called Themis is essential for proper development of T cells.
- Specialized Skin Helpers
A new type of immune cell that is dedicated to combating skin infections is identified in two papers.
- A New Genetic Variant Influences Risk of Atrial Fibrillation
A new genetic variant associated with increased susceptibility for atrial fibrillation, a prominent risk factor for stroke and heart failure, is reported.
- A Common Susceptibility Locus for Several Types of Cancer
Genetic variants near two genes on the chromosomal locus 9p21 increase the risk for multiple types of cancer, including glioma, basal cell carcinoma, and melanoma.
- Cycling for Neurodegeneration
A novel method of disrupting abnormal protein deposits in the brain associated with neurodegenerative disease is presented in a study.

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