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  June 20, 2021
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2007-04-13
- Scientists identify a candidate gene for osteoporosis
Gene may underlie differences between African Americans and Caucasians
2007-04-05
- Genetic Factors In Congenital Diaphragmatic Hernia (Abstract)
This review examines key findings in the growing body of evidence that genetic factors play an important role in the development of Congenital diaphragmatic hernia (CDH).
- Heterozygous Mutations In TREX1 Cause Familial Chilblain Lupus And Dominant Aicardi-Goutières Syndrome (Abstract)
Scientists report a heterozygous TREX1 mutation causing familial chilblain lupus.
- Preventing Cancer Without Killing Cells
Inducing senescence in aged cells may be sufficient to guard against spontaneous cancer development.
- Autoantibody Production By Perturbed B Cells
Chronic low-level expression of a molecule called 'thymic stromal lymphopoietin' (TSLP) can greatly alter the development of antibody-producing B cells.
- Prostate Cancer Risk Variants
Several newly identified genetic variants on chromosome 8 are associated with increased risk of developing prostate cancer.
- Genetic Variant Associated With Susceptibility To Osteoarthritis
A variant in a gene called GDF5 is associated with the risk of developing osteoarthritis.
- From A And B To O: Towards Universal Red Blood Cells
A way of converting blood from groups A, B and AB into group O is described.
- 'Semi-Identical' Twins Discovered
Researchers have discovered a pair of twins who are identical through their mother's side, but share only half their genes on their father's.
- A Light-Switch For Brain Cells
An elegant technique using light to control the activity of brain cells is described.
2007-03-29
- Genes behind fatal lung disease identified
Scientists at Maryland's Johns Hopkins University say they have identified the genetic mutations that trigger a hereditary form of fatal lung disease.
2007-03-26
- Scientists identify a gene that may suppress colorectal cancer
Gene study hints at potential new target for cancer therapy, detection and prevention
- Calcium Plaque Build-up in the Arteries Leads to Coronary Heart Disease in Multi-Ethnic Groups
Low Calcium Build-up in certain ethnic groups can still mean the same risk as high calcium build-up in other ethnic groups.
- Tiny, Spontaneous Gene Mutations May Boost Autism Risk
Spontaneous deletions and genetic duplications were found to be ten times more prevalent in sporadic cases of autism spectrum disorders.
- Cancer-Specific Imaging in Mice
New imaging compound in mice that selectively binds to certain cancer cells and glows, or fluoresces, only when processed by these cells.
- Surprising Pattern of Influenza Spread in South America and Tropics
Influenza epidemics found to spread from the equator towards more populous regions of the Southeast and South of Brazil.
2007-03-21
- Whole Genome Association Reveals Schizophrenia Gene
A genetic basis for schizophrenia found on both the X and Y chromosomes, is presented.
- A Potential Therapeutic Agent For Retinoblastoma
A natural agent derived from the bark of the South-American lapacho tree inhibits growth and induces cell death in human retinoblastoma cell lines.
- Novel Pathway For Antibiotics-induced Cell Death
Scientists have identified unforeseen mechanisms by which quinolones - a family of broad-spectrum antibiotics among the most widely prescribed - induce bacterial cell death.
- Green Tea May Help To Fight Lung Cancer
A possible mechanism for green tea's anticancer activities is reported.
- Laying Sleeping Sickness To Rest
The parasite that leads to sleeping sickness can be lulled to sleep itself using a newly discovered pathway.
- Jumonji Family Removing The Mark
Two papers identify a sought-after regulator of 'marks' on the chromatin that are associated with whether the genes are switched on or off.
- How Stress Causes Anxiety In Adolescent Mice
Stress may cause anxiety in adolescents due to an atypical response to a neurosteroid.
- A Cheap Alternative For Large Scale RNA Interference Screens
A cost-effective resource for RNA interference (RNAi) that allows the effective reduction of gene expression is presented.
- Bacteria-mediated Immune System Paralysis
How the pathogen Staphylococcus aureus, a leading cause of hospital-related infections, disables the immune system is described.
- Understanding Cancer Spread
A signalling pathway that enhances the formation of metastases in a mouse model of prostate cancer has been identified.
- Cancer Genomes Probed
Biologists have sequenced over 500 protein kinase genes found in 210 diverse human cancers and identified over 1,000 different mutations.
- Transcription Factor SIX5 Is Mutated In Patients With Branchio-Oto-Renal Syndrome
Study identified heterozygous mutations in the second member of the SIX family of proteins, unc-39 (SIX5), as a novel cause of Branchio-oto-renal syndrome.
- Most Rare Missense Alleles Are Deleterious In Humans
Results imply that mutation-selection balance may be a feasible evolutionary mechanism underlying some common diseases.
- Kalirin Gene: A Novel Candidate Gene For Coronary Artery Disease
Data suggest the importance of the KALRN gene and the Rho GTPase–signaling pathway in the pathogenesis of Coronary Artery Disease.
- Gene Therapy Progress And Prospects: Ultrasound For Gene Transfer
Ultrasound exposure in the presence of microbubbles (MCB) increases plasmid transfection efficiency in vitro by several orders of magnitude.
- Sotos Syndrome
The NSD1 mutational spectrum has been defined, the phenotype of Sotos syndrome clarified and diagnostic and management guidelines developed.
- Evidence Of A Spinal Motor Neuron Neurotrophic Factor
Pleiotrophin, or heparin binding neurotrophic factor, promotes regeneration of peripheral nerve axons after sciatic nerve transaction.
2007-03-15
- A New Approach To Cancer Therapy
Turning off an endogenous inhibitor to the p53 apoptotic pathway causes tumor regression.
2007-03-14
- Schizophrenia Treatment Trial Demonstrates the Benefits of Antipsychotics
Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE) provide more data regarding the extent antipsychotic medications help people with schizophrenia.
- Parents Who Live Long Pass On Lower Risk of Cardiovascular Disease
People whose parents live longer are more likely to avoid developing high blood pressure, high cholesterol, and other risk factors for cardiovascular disease in middle age than their peers whose parents died younger.
- NIDA Launches First Large-Scale National Study to Treat Addiction to Prescription Pain Medications
The study is a response to the growing national problem of prescription drug abuse in the United States.
- More Data Opioid Receptor’s Role in Alcohol Pleasure and Problems
Researchers explored the link between genetic variants of mu-opioid receptors and alcohol-related behaviors in a group of 82 rhesus monkeys.
2007-03-08
- Imatinib Could Cause Tumour Regression
The first targeted anticancer drug to specifically inhibit an enzyme that causes cancer cell growth might also promote tumour regression.
- The Connectivity Map Of Multi-Drug Combinations
The response to drug combinations critically depends on how their biological targets are connected.
- New Way Of Targeting Gene To Treat Breast Cancer
A new way of targeting the PARP1 gene in order to induce cell death in breast cancer cells is reported.
- X-Linked Adrenoleukodystrophy - Newborn Screening And Lorenzo's Oil
Promising methods of screening for and treating X-linked adrenoleukodystrophy (X-ALD) are highlighted.
- Potential Therapeutic Target In Down Syndrome
Blocking the actions of an inhibitory neurotransmitter can improve performance in several memory tasks in a mouse model of Down syndrome.
- Proteins A La Carte
A method to incorporate non-naturally occurring amino acids into proteins in mammalian cells is described.
- Genomic Marker For Lung Cancer
Gene expression patterns in lung airway cells from smokers may aid the early detection of lung cancer.
- A Natural Barrier To HIV Transmission
A protein in one of the first immune cells encountered by HIV as it enters the body acts as a natural barrier to transmission of the virus.
- New Immune Cell Exit Strategy
Immune cells recruited to sites of infection can use more than one type of molecule to exit the bloodstream.
- Mitochondrial Point Mutations Do Not Limit Lifespan
A large number of point mutations in mitochondria do not have a direct link to the ageing process in mice.
- Genetic Variant Protects Against Four Infectious Diseases
A genetic variant associated with protection against four different infectious diseases is described.
- Genetic Variant Associated With Triglyceride Levels
Scientists have identified a rare genetic variant that is associated with lower levels of triglycerides.


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