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  June 14, 2024
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- Target Identified For Dengue Therapy
Scientists have identified a molecule targeted by dengue virus in mice to bring about the haemorrhagic fever associated with lethal disease.
- How A Vaccine Enhancer Works
A paper finally reveals how alum boosts the biological agent's effect in stimulating a protection response by the recipient's immune system for different vaccines.
- Getting To Grips With Self-Renewal
Embryonic stem cell (ESC) renewal does not rely on instructions from outside the cell and can be enabled by eliminating internal factors that induce differentiation.
- Molecular Clues To Appetite And Drug Addiction
Researchers have discovered a new molecular mechanism that underpins the brain's responses to food and drugs of abuse, such as cocaine.
- Towards A Model For Huntington's Disease
Progress towards developing a non-human primate model for Huntington's disease is reported online.
- Fat Chance: Brown vs. white fat cell specification
Discoveries could lead to new treatments for obesity and diabetes
- Effect of Mutant p53 Stability on Tumorigenesis and Drug Design
Targeted drugs could help or hurt depending on the tumor's p53 status
- Fighting Glioma-Associated Edema
Excessive accumulation of fluid in the brain can be prevented by inhibiting glutamate transport to prolong survival.
- Strength In Numbers
A large number of signalling motifs in the receptor complex expressed on the surface of T lymphocytes helps prevent autoimmunity.
- Generating Human Autoimmune Cells
The essential 'ingredients' for producing a type of human immune cell involved in both mucosal immunity and autoimmunity are reported online.
- Genetic Susceptibility To Obesity
Scientists have discovered genetic variants that increase the risk of obesity and insulin resistance in the general population.
- Stopping DNA Synthesis Before It Starts
A small-molecule inhibitor of Cdc7 kinase prevents DNA synthesis and has antitumour activity.
- Stem-Cell Regeneration Of The Breast Relies On Adhesion
Interaction of basal stem cells in the breast with their cellular environment is crucial for their function, and helps towards the regeneration of the mammary glands during pregnancy.
- Targeting Dormant Leukaemia Cells
A new role for a protein involved in leukaemia is described.
- Insight Into Devastating Pregnancy Condition
A paper published online has identified two culprits likely to trigger pre-eclampsia if they are in short supply, opening up the possibilities of early diagnosis and even treatment of the disorder.
- Starting Out On The Road To Maleness
A study of mice now shows how developing gonads start out on the road to maleness.
- Why We Are All Different
A paper takes a close look at the larger DNA variations that influence differences between individual humans and their potential origins and evolutionary history.
- New Program For Analysis Of Haplotype Associations
A paper describes a new program for the analysis of haplotypes in the context of genetic association studies
- A Rogue Neighbourhood
Gene expression changes in the tissue microenvironment in which a tumour arises can be used to predict outcome in patients with breast cancer.
- Focus On Natural Killer Cells
A series of articles explore the behaviour of the enigmatic lymphocytes (natural killer - NK - cells), and reflect on their transition from outcasts of mainstream immunology to prominent players in innate immunity.
- Sequencing Sheds Light On The Cancer Genome
The rearrangement of genomes in people with lung cancer can be identified using an approach called 'massively parallel sequencing.'
- Inflammatory Bowel Diseases Share Genetic Risk Factors
Several genetic risk variants are identified for the common inflammatory bowel disease ulcerative colitis.
- Breast Cancer Risk Variants
Two common genetic variants on chromosome 5 increase susceptibility to certain types of breast cancer breast cancer.
- Why We Are All Different
A paper takes a close look at the larger variations within human DNA and their potential origins and evolutionary history.
- Test-Tube Recipe Makes Functioning Heart Cells
A Canadian, US and British research team has successfully grown three types of human heart cells from cultures derived from embryonic stem cells.
- Sequencing Gets Personal
Two months and less than $1 million is all it takes to sequence an individual genome.
- Helping The Immune System
Researchers identify a protein involved in blood circulation in tumours and demonstrate that deleting it opens up the tumour to the immune system.
- Molecular Basis for Neurodegeneration in Ataxia telangiectasia
Ataxia telangiectasia (ATM) gene has been found to regulate the cell cycle in neurons, so cell cycle inhibitors may have therapeutic potential in A-T
- Researchers Make New Finding about How Memory is Stored
Localized protein destruction regulates nerve cell connections
- 'What' And 'Where' In Auditory Cortex
A study published online reports conclusive evidence for auditory brain areas being segregated by whether they contribute to recognizing an object -- the 'what' pathway -- or processing where an object is located -- the 'where' pathway.
- Decisions Occur Before Awareness
Activity in certain areas of the brain signals what choice people are going to make up to ten seconds before they become consciously aware of their decision.
- Host-To-Graft Disease Spread In Parkinson Disease?
Cell transplants have long been proposed as a possible therapy for Parkinson disease, but a series of reports suggest that the pathology may spread from the host to the transplants.
- Common Genetic Variants Influencing Adult Height
Scientists have discovered dozens of common genetic variants influencing adult human height, according to three studies published online.
- Arsenic Action On Leukaemia
Scientists have identified the mechanism by which compounds of arsenic can actually have therapeutic properties when used to treat certain types of cancer.
- p53 Hampers Energy Metabolism In Cancer Cells
The tumour suppressor p53 can limit tumour development by inhibiting aerobic glycolysis.
- Pinpointing Lymphoblastic Leukaemia Lesions
Scientists identify another mutant protein that causes bone marrow cells to multiply uncontrollably in ALL (acute lymphoblastic leukaemia) patients.
- How Synaptic Activity Protects Neurons
Scientists have identified a key signalling pathway that could protect areas of the brain at risk of damage from ageing and neurodegenerative diseases.
- A New Therapy Of Cystic Fibrosis
A potential treatment for cystic fibrosis has been identified in mice.
- The Best Of Both Worlds
The creation of a combined positron emission tomography (PET) and magnetic resonance imaging (MRI) scanner is reported online.
- Therapeutic Cloning Treats Neurodegenerative Disease
Therapeutic cloning can be used to treat Parkinson's disease in mice.
- Colorectal Cancer Risk Variants
Three new variants are associated with increased risk of colorectal cancer.
- New Genetic Risk Factors For Type 2 Diabetes
At least six regions of the genome harbor variants that predispose to type 2 diabetes.
- RNA Trojan Horses Zero In On Liver Cirrhosis
Using vitamin A to target the cells that cause liver cirrhosis may improve the treatment of the disease.
- Route To Thwarting Skin Cancer
A paper has identified how the cells in epithelial tumours signal to one another in order to keep the population of rogue stem cells topped up.
- Moving In On Drug Resistance
A paper in reveals a mechanism of how antifungal drugs have the unwanted effect of boosting the fungus' arsenal of pumps used to fight them off.
- Smoking Receptors Mirror Lung Cancer Genes
A region on chromosome 15 that hosts three nicotine receptor subunit genes is associated with risk of lung cancer.
- MicroRNA Silencing In Non-Human Primates
Researchers have effectively silenced microRNAs (miRNAs) in monkeys for the first time, targeting a liver-specific miRNA and reducing blood cholesterol as a result.
- Genetic Blindness Treatments Emphasize Immune Role
A promising treatment for age-related macular degeneration - responsible for up to 50 million cases of blindness worldwide - works by a more general mechanism than had previously been thought.
- Novel Fullerene Shows Potential For Secondary Progressive Multiple Sclerosis
A water-soluble fullerene-NMDA receptor antagonist hybrid prevented disease progression in an animal model, by protecting against axonal loss and demyelination.
- A Novel Search Engine for Disease Genes
Rapidly Identifying Genes Associated with Hereditary Disease and Cancer

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