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  May 21, 2024
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- Cancer Gene Therapy: All of p53
The fight against cancer takes a step forward with the online publication of a 50 page review on p53.
- Complement Enhances Tumour Evasion
A seemingly illogical link between activation of immune sensors and the ability of tumours to escape the immune system is reported online.
- Survival Strategies
Scientists have discovered a molecule that helps activated immune cells survive in the face of massive amounts of the antimicrobial signalling protein, interferon-gamma.
- Risk Factor for Narcolepsy
A genetic variant that predisposes to narcolepsy has been identified.
- Fatty Liver Disease
Scientists have discovered common genetic variants influencing susceptibility to nonalcoholic fatty liver disease.
- Thwarting Tumour Invasion
A mechanism used by metastasising tumour cells to invade lung tissue and establish secondary tumours is reported.
- A new ranking of scientific journals
A paper describes a new ranking of scientific journals
- Twin Studies Point to Genetic Variability Among Different Populations
Twin studies from eight populations show that genetic mechanisms for height, weight and BMI are more variable than researchers previously suspected.
- The Tuberculosis Bacterium's Stealthy Ways
Mycobacterium tuberculosis -- the bacterium that causes most cases of tuberculosis -- spreads infection by blocking a naturally triggered immune response that would cause the infected cells to die.
- Coping with Immune Cell Death
Researchers have discovered a 'sensor' molecule that alerts the immune system to the presence of necrotic cells.
- Risk Factor for Common Kidney Disease
Scientists have identified the first common genetic variants that increase risk of end-stage kidney disease (ESKD).
- Susceptibility to Bladder Cancer
Researchers have found a genetic variant associated with increased risk of urinary bladder cancer.
- Enzyme Associated with Vitamin B12 Levels
Scientists have identified the first genetic variants that contribute to variation in levels of vitamin B12.
- New Approach for Leukaemia Treatment?
Drugs that block the action of an enzyme called glycogen synthase kinase (GSK3) may prove useful in treating a particular type of poor prognosis leukaemia.
- Invasion Proteins Target Placenta
Researchers may have figured out how a disease-causing bacteria crosses the placenta from mother to baby.
- New Colon Tumour Gene Gives Fresh Therapeutic Lead
Cancer researchers have identified a gene that promotes the growth of colon cancers, potentially creating a new avenue for treating many cases of the disease.
- Blood 'Fingerprints' For Cancer
Serum microRNAs (miRNAs) can serve as biomarkers for the detection of diseases including cancer and diabetes.
- Why The Brain Makes New Nerve Cells
The adult brain requires a continuous stream of new neurons for the maintenance of regions controlling smell and spatial navigation.
- Inherited Risk Factors For Common Leukemia
Scientists have produced the first unequivocal evidence for inherited factors that contribute to susceptibility to chronic lymphocytic leukemia (CLL).
- Telomerase Structure Revealed
Researchers have snuck a peak at the engine of telomerase, an important enzyme that aids chromosome stability.
- Genetics Of Geography
By analyzing small areas of genetic variation known as single nucleotide polymorphisms, scientists have uncovered a surprising link between genes and geography.
- Exploitative Tricks Of Antibiotic-Resistant Bacteria
Antibiotic treatment may compromise the innate immunity of the intestine.
- Stem Cells Classified
A new method for classifying stem cells should help researchers distinguish one stem cell type from the next.
- Predisposition Gene For Childhood Cancer
A gene responsible for the majority of inherited cases of a common childhood cancer is reported online.
- A Potentially Dangerous Molecule On The Loose
A paper reveals how a protein called PTEN, as a result of losing its ubiquitin tag, can cause it to break loose from the cell nucleus and stop it carrying out its normal function of nipping potential cancers in the bud.
- Switching Fat To Lean
In two related studies, scientists identify the factors that regulate fat formation; this research could help to develop new therapies to tackle obesity.
- Venter Versus Watson
Personalized medicine should employ precise genetic information instead of relying on race and ethnicity to prescribe drugs in the future.
- Moisturizers Increase Skin Cancer Risk In UV-Radiation Treated Mice
everal common moisturizing creams can increase the formation of non-melanoma skin tumors when applied to UV-radiation treated mice.
- Nature Reviews Genetics: An Ever-Evolving Review
An article highlighting new ways of using the interactive web to generate community-driven reviews of scientific knowledge will be subject to some of its own recommendations.
- Staying Lean Without A Diet
A study published online reports a strain of mice that are lean and resistant to obesity.
- An Antibacterial Catapult
Scientists have discovered an immune cell that fights bacteria by throwing mitochondrial DNA in a catapult-like manner.
- Cleaning Up The House
Boosting the activity of a cellular quality-control mechanism may prevent the functional decay associated with ageing.
- New Susceptibility Gene For Type 2 Diabetes
Scientists have identified variants that increase risk of type 2 diabetes in populations of both East Asian and European origin.
- Ion Channels Implicated In Bipolar Disorder
Variants in two genes are associated with increased risk of bipolar disorder.
- Genetic Risk Factor For Chronic Inflammatory Disorder
A genetic variant that increases risk of the chronic inflammatory disorder sarcoidosis has been identified.
- Cancer Taking The Myc
Therapies that block the action of a gene called Myc may prove useful against cancer.
- Key Receptor Identified For HCMV Infection
Researchers have identified a critical receptor required for human cytomegalovirus (HCMV) infection.
- Mapping and Cloning Genes - Goodbye to All That?
A paper describing the use of whole-genome deep sequencing to pinpoint mutations in the worm C. elegans is published; in principle, this approach be applicable to any model organism whose genome has been sequenced.
- Sex in Bacteria for Genome-wide Interaction Screens
Two papers describing techniques for genome-wide genetic interaction screens in bacteria are published.
- Pre-eclampsia May be an Autoimmune Disease
A pre-eclampsia-like syndrome can be induced in mice by giving them autoantibodies isolated from humans with the disease.
- A Great Warm-up Act
Promoting blood vessel growth and tissue remodelling may improve outcome in patients with muscular dystrophy.
- Avoiding Attack When Not Stressed
A study explains the process how healthy cells express a panel of microRNAs that help avoid unwanted recognition and attack from the immune system., and suggests the same mechanism may also help tumours to go undetected.
- Mediating Restraint
Scientists report that a molecule called CD200R exerts a dampening effect on specific immune cells residing in the lung.
- Research Agenda for Personalized Genomics
A multifaceted research agenda is urgently needed to reap the full benefits and avoid the potential pitfalls of personalized genomics.
- Enzyme Implicated in Restless Legs Syndrome
A new genetic variant has been implicated in risk of restless legs syndrome.
- Unlocking the Door to HIV Infection
The structure of the protein complex responsible for unlocking cells to enable HIV entry is reported.
- The Impact of microRNA on Proteins
The consequences of protein regulation by microRNAs (miRNAs) are studied on a large scale in two papers.
- Genetics for Mental Health Disorder
Specific human genomic variations associated with schizophrenia are identified by three research groups.
- Family History of Pancreatic Cancer in a High-Risk Cancer Clinic: Implications for Risk Assessment
A case-control design was used to investigate the importance of a family history of pancreatic cancer (PC) to cancer risk assessment.
- Health Behaviors and Psychological Distress in Women Initiating BRCA1/2 Genetic Testing: Comparison with Control Population
Study looked at breast cancer screening practices, lifestyle behaviors and psychological distress among 640 women initiating BRCA1/2 testing.

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