home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Engineered DNA 'Scissors' Show Promise

 
  November, 14 2008 4:49
your information resource in human molecular genetics
 
     
A molecular 'pair of scissors' that snips out specific chunks of DNA has yielded promising results both in vitro and in cells. It is hoped that the engineered protein, reported in Nature, will lead to treatments for xeroderma pigmentosum and other diseases caused by mutations in single genes.

Patients with xeroderma pigmentosum have a faulty DNA repair pathway and are hypersensitive to ultraviolet light; for this reason, afflicted individuals are particularly prone to skin cancer. Guillermo Montoya and his colleagues have engineered two enzymes that can cleave DNA from the human xeroderma pigmentosum group C gene in vitro and in cellular experiments. The engineered proteins are based on a wild-type homing endonuclease - called I-CreI - which recognizes and cleaves specific DNA sites, and they seem to work by a similar mechanism.

CONTACT

Guillermo Montoya (Spanish National Cancer Center, Madrid, Spain)
E-mail: gmontoya@cnio.es

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.