home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Neuronal Contribution to Risk of Multiple Sclerosis

 
  November, 14 2008 5:10
your information resource in human molecular genetics
 
     

The first risk variant for multiple sclerosis in a gene expressed specifically in neurons has been identified, according to a study published online in Nature Genetics.

Multiple sclerosis is a complex autoimmune disease in which the immune system attacks and destroys the myelin sheath surrounding nerve fibres, resulting in neurodegeneration. Only a very small number of genetic variants have been shown to increase risk, and each is found in genes with functions in the immune system.

Rogier Hintzen and colleagues carried out a genome-wide association study of affected Dutch, Swedish and Canadian individuals, and report a variant in the gene KIF1B to be associated with susceptibility to the disease. KIF1B is enriched in motor neurons, and is a member of a family of proteins involved in transport of cellular components along neuronal axons. This process has been implicated generally in neurodegenerative diseases, and the authors suggest that defective axonal transport may contribute to the pathogenesis of multiple sclerosis as well.

Author contact:

Rogier Hintzen (Erasmus Medical Center, Rotterdam, The Netherlands)
E-mail: rhintzen@xs4all.nl

Abstract available online.

(C) Nature Genetics press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.