home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Combating Muscle Fatigue

  October, 30 2008 3:24
your information resource in human molecular genetics

Researchers have identified a potential cause of fatigue in patients with neuromuscular diseases such as Duchenne muscular dystrophy. The findings, published this week in Nature, could lead to new treatments that improve the quality of life for these patients.

Patients with neuromuscular disorders experience extreme fatigue after even the mildest of exertion. Kevin Campbell and colleagues find in mice with similar disorders that this is caused by a lack of a particular molecule in the membranes of muscle cells - neuronal nitric oxide synthase (nNOS). The team find a similar deficit in nNOS in tissue samples from patients with a wide range of disorders, suggesting a shared mechanism of fatigue.

In healthy muscles, nNOS signalling widens blood vessels to help them recover faster after exercise. Treating diseased mice with drugs that mimic the effects of nNOS had a similar effect, allowing the mice to regain activity after exercise much faster. The results suggest that a similar strategy could be used to treat patients.

Author contact:

Kevin Campbell (University of Iowa, Iowa City, IA, USA)
E-mail: kevin-campbell@uiowa.edu

Abstract available online.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.