| 2009-07-17 |
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Getting to the Root of Oculo-Facial-Cardio-Dental Syndrome
An insight into the underlying causes of oculo-facial-cardio-dental syndrome (OFCD) is provided online.
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Korean Genome Sequenced
The genome sequence of a Korean individual (AK1) is revealed, adding further to our understanding of ethnic diversity and the individual variation underlying complex traits and disease.
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Gene Implicated in Germ-Cell Development
A screening method using cultured, differentiated mouse embryonic stem (ES) cells has identified Lin28 as an important gene in the formation of germ cells.
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MicroRNA Implicated in Cell Fate Decisions
Two microRNAs, single-stranded RNA fragments known to influence gene expression, have been shown to regulate cell fate decisions.
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| 2009-07-02 |
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HAART to Heart
'HIV-infected' patients with normal blood pressure, who are on certain anti-virus drugs, are more likely to have a high level of arterial stiffness that is similar to otherwise healthy patients with high blood pressure.
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Biomarker for Diabetes
The metabolic hormone adiponectin could serve as a predictive biomarker for type 2 diabetes.
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Inside The Brain of an Elite Athlete
Recent research into the differences in neural and cognitive processing between skilled sportspeople and novices is reviewed.
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Mystery Solved For Immunoglobulin D Role
A study reports that immunoglobulin D helps combat upper respiratory infections.
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Uncovering Allergy Bias
A gene that helps explain why some individuals are more likely to develop allergies is reported.
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Genetic Variants Associated With Kidney Stones
Common genetic variants are associated with an increased risk of kidney stone disease.
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Stopping the Pumps in Chemotherapy-Resistant Tumors
A novel type of artificial drug delivery system that blocks cancer cells' ability to expel chemotherapy and thereby acquire drug resistance is published.
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How Cells Get A LIF to Pluripotency
A rare insight into how pluripotency is maintained in mouse embryonic stem (ES) cells is published.
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'Ethical' Stem Cells Under The Spotlight
Most, if not all, cell types in the body can be reprogrammed to become stem-cell-like.
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Heart Progenitors Yield Diverse Cell Types
A newly identified set of human cardiovascular progenitor cells can give rise to the three major cell types found in the heart.
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Genetic Variants Associated With Schizophrenia
Three papers provide new insights into genetic variation and schizophrenia risk.
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Cancer Protein May Prove Useful Biomarker
A new cancer-causing gene with biomarker potential is revealed.
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Thalidomide Birth Defects Not a Patterning Problem
Thalidomide-induced limb abnormalities may reflect a 'precursor' rather than a 'patterning' problem.
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Evolution of a Malaria Resistance Gene in Wild Primates
A genetic variation has been linked to the emergence of malaria resistance in wild baboons.
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Protein Links Fasting and Stress
A single protein can 'sense' fasting signals and a potentially damaging form of cellular stress.
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Jogging Your Memory
A common immunosuppressive drug can enhance immune responses to experimental vaccines in mice and monkeys.
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| 2009-06-19 |
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Smog Stresses the Skin
Ozone may have damaging effects on a skin enzyme that helps break down environmental pollutants.
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Odds on Serotonin Regulating Gambling Impulses
Rats can learn to play the odds, which is useful because it helps shed light into how the brain regulates gambling behavior.
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Play It Again
A published paper differs from previous theories that suggest that only replay during sleep is important for memory.
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How Nanotubes Suppress the Immune Function?
Inhalation of carbon nanotubes activates cellular signals in the lung, which in turn activate signals in the spleen to suppress the immune function of mice.
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Activating Genes In Live Animals
Tools to precisely regulate gene expression in single cells or whole organisms are reported.
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Nanomaterials in Biological Systems
State-of-the-art understanding of the interactions between nanomaterials and proteins, cells, DNA and other biological surfaces is reviewed.
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Genome Screens Suggest Clues to Multiple Sclerosis Risk
Several common gene variants point to ways in which individuals vary in their susceptibility to the autoimmune disease, multiple sclerosis (MS), according to two studies.
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New Drug Target for Leukaemia
A genetic change in leukaemia cells that is essential to their proliferation, but also makes the cells vulnerable to an existing drug, has been identified.
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Alzheimer's Assemblies Identified
Assemblies of twelve units of the protein amyloid-beta42 are a probable key neurotoxic agent in the development of Alzheimer's disease.
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Can Alzheimer's Disease Be Infectious?
Tangles observed in the brains of Alzheimer's patients induce the formation of similar inclusions when injected into the brains of healthy mice.
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Protein Translation Factor Causes Breast Cancer
Factors that cause a particularly aggressive form of breast cancer are reported online.
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Getting Into the CNS
Clues as to how leukaemia cells can get into the central nervous system (CNS) are reported.
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Copy Number Variation Linked to Neuroblastoma
The presence of a particular DNA copy number variant (CNV) may be associated with the development of an aggressive, often fatal type of childhood cancer of the sympathetic nervous system.
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Sperm DNA Packaging
A paper provides insights into how DNA in sperm is packaged during development, which could reflect the role the paternal genome has in the embryo.
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A New Vision for Eye Condition
A potential detection marker for age-related macular degeneration (AMD) is reported.
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| 2009-06-04 |
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Listen Up: Focus on Hearing
Seven perspective and review articles cover recent advances in our understanding of how sounds are converted into neural signals, how these processes go wrong in hearing loss, and what attempts to rectify such hearing loss tell us about brain function.
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Suppressing Suppressors
The discovery of an inhibitory signaling circuit that blocks the generation and function of regulatory T cells is reported.
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Genome Scan Uncovers Genetic Risks of Testis Cancer
Gene variants accounting for some of the differences between men in their risk of developing testis cancer have been identified.
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Genetic Variation Influences Adverse Reaction to Common Antibiotic
A common genetic difference between people influences their chance of developing a rare but serious liver injury as a side effect of taking the antibiotic flucloxacillin.
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How Do Inhibitors Activate Kinases?
Inhibitor binding leads to pre-activation of two kinases.
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Targeting Muscle Disorders
A molecular link between the loss of function of the enzyme MIP/MTMR14 and the muscle defects in mice is reported.
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Genetic Reprogramming
Researchers have generated stem cells from patients with a rare genetic disease, corrected the cells' defect and reprogrammed to pluripotency.
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DNA Genie Bottle Assembles Itself
A variety of complex self-assembled DNA shapes are revealed.
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How Down's Syndrome Protects
A genetic explanation for why people with Down's syndrome have a reduced incidence of solid cancers.
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Nature Precedings: A preprint server for biomedical sciences
A new online platform for the posting and sharing of preliminary findings and preprints
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| 2009-05-21 |
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Experience-Dependent Brain Changes in Angelman Syndrome
Sensory-experience dependent modification of visual areas in the brain are disrupted in a mouse model of Angelman syndrome (AS).
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Coordinated Memory
Brain areas known to be involved in emotions and learning are more coordinated with each other during learning.
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Gene Transfer Protects Monkeys against SIV Infection
Delivering an antibody-coding gene to the muscle of monkeys protects them against the infection simian immunodeficiency virus (SIV).
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Interleukin 17: A Jekyll and Hyde of the Immune System?
Interleukin 17 (IL-17) -- a soluble factor thought to promote inflammation and autoimmunity -- can actually suppress the onset of inflammatory bowel disease.
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Gene Variants to Set Your Biological Clock By
Genes may provide some clues to the variation in the age at which a woman gets her first and last menstrual period according to five independent studies.
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