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  June 14, 2024
your information resource in human molecular genetics
- Using statistics to decipher secrets of natural mutation
New mathematical approach for analyzing the complex, subtle patterns of natural mutation in DNA
- 'Smart Gene Therapy' Protects Against Damage From Heart Attack
Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injury
- Molecular Link Between Inflammation And Cancer
Inactivation of Pro-Inflammatory Gene Dramatically Reduces Tumor Development
- Got the time?
Development of a molecular timetable by analysis of circadian gene expression
- Location of Potential Familial Lung Cancer Gene Discovered
A major lung cancer susceptibility locus maps to chromosome 6q23-25.
- Gene Expression Pattern May Predict Behavior of Leukemia
Expression pattern of miRNA genes in CLL correlated with a deletion of a chromosomal region and with mutations in the Ig gene
- Genome-wide discovery of loci influencing chemotherapy cytotoxicity
New technique helps scientists reveal interactions between genes and drugs
- Malignant cancer cells generate mice through cloning
Nature can reset the clock in certain types of cancer and reverse many of the elements responsible for causing malignancy
- Gene therapy reaches muscles throughout the body and reverses muscular dystrophy in animal mode
Researchers have found a delivery method for gene therapy that reaches all the voluntary muscles of a mouse -- including heart, diaphragm and all limbs
- Researchers Look Into Components Of RNA Silencing Machinery
DNA methylation is independent of RNA interference in Neurospora
- Synthetic Prion Causes Neurological Disease In Mice
The findings demonstrate that prions can make copies of themselves without the presence of viral DNA or RNA, damage brain tissue, and cause neurological diseases
- Research Reveals Reveals Gains Or Losses Of Large Segments Of DNA In Healthy People
These findings point to possible new explanations for individual uniqueness as well as why disease develops
- Researchers Uncover Surprising Degree of Large-Scale Variation in the Human Genome
Implications Seen for Cancer, Neurological Disorders, and Other Diseases
- Brain Serotonin Enzyme Finding Might Explain Psychiatric Disorders
Tryptophan hydroxylase-2 controls brain serotonin synthesis
- Genetic Mutation Found That Is Major Contributor To Type 1 Diabetes
A natural mutation of a gene that helps regulate the reactivity of the immune system is a major contributor to type 1 diabetes
- New Database Focuses on Genetic Policy and Laws
NHGRI Launches Free Web-based Resource For Finding Federal, State Laws Related to Genetic Issues
- Multitasking Protein—Nature’s Defense Against Retroviruses
Mammalian cells have evolved an arsenal of genes that fend off invading retroviruses and inhibit cross-species transmission.
- Server to search for genetic diversity
The server is called PDA (Pipeline Diversity Analysis)
- Dog Genome Assembled
Canine Genome Now Available to Research Community Worldwide
- New technique for rapidly identifying the functions of genes
The "high throughput" technique can be used in both cell culture and in animal models to screen thousands of genes for a particular biological function.
- A better way to copy DNA
Scientists have developed a new method for DNA amplification that could replace the polymerase chain reaction (PCR)
- Combination Of Gene Therapy And Gene Silencing Prevents Neurodegenerative Disease
Prevention of physical symptoms and neurological damage caused by spinocerebellar ataxia 1 (SCA1).
- Cancer gene MYC emerging as key research target
New Technologies Are Shedding Light on MYC's Complex Functions
- The Key to Cell Motility
Rac controls a number of biological processes and is directly implicated in several human diseases.
- Researchers find protein to stall HIV
The new protein (called APOBEC3F) and one described previously (APOBEC3G) can directly mutate HIV.
- Earliest Evidence of Hereditary Genetic Disorder
The fossil is dated as 1.5 million years old.
- Researchers Discover Receptor Molecule for Key Diabetes Protein
T-cadherin, is located on cell surfaces in blood vessel linings, the heart, and muscle tissue.
- Second-Generation Antisense Inhibitors Provide New Insights Into Metabolic Disease and Potential Treatments
Isis and Collaborators Present Data From 4 Preclinical Studies at American Diabetes Association Annual Meeting
- Genetic vaccine promising against chronic hepatitis C
HCV NS3-based genetic vaccines effectively primed both humoral and cellular immune responses in mice.
- Newly grown kidneys can sustain life in rats
Researchers take critical first step toward using animal tissue transplants to treat kidney failure
- NIH Launches First Center In Nationwide Chemical Genomics Network
Initiative Will Generate New Tools to Accelerate Study of Human Disease
- A Gene That Keeps Species Apart
Daniel Barbash and colleagues identify a true speciation gene in the fruitfly Drosophila.
- Therapeutic cloning may be permitted at Newcastle University
A special licensing committee of the UK Human Fertilization & Embryology Authority (HFEA) met to decide whether to grant a license to scientists at The Center for Life at Newcastle University.
- Alzheimer's May Leave Some Forms of Memory Intact
People with Alzheimer's disease retain a specific form of memory used for rote learning of skills, even as their memories of people and events are extinguished.
- Researcher Issues Caution On Live Virus Vaccines
Live virus vaccines to prevent infectious diseases like West Nile virus and yellow fever could have dire consequences.
- Keeping Drugs Stable Without Refrigeration
Rapidly solidified sugars preserve proteins best when they suppress tiny, molecular motions lasting a nanosecond or less.
- Gene Related To DNA Repair And Cancer Risk
A protein long thought to be involved in repairing DNA that is damaged during normal metabolic processes is linked to tumour suppression.
- Drug Tested At OHSU Prevents MS-like Disease In Animals
LGD5552, a non-steroidal selective glucocorticoid receptor modulator, prevented disease development when tested on animal models.
- New Method to Identify Blood Proteins May Spur Novel Disease Marker Discoveries
Using conventional technologies, researchers have developed a new method for identifying proteins found in trace quantities in the blood.
- Genes Promoting Nerve, Other Cell Communications May Have Come From Bacteria
Cell-signaling molecules may play a role in learning, memory, mental alertness, sleep patterns, and allergic responses.
- Renal Physicians and NIH Release Web Tool to Coordinate Care for Kidney Patients
Nephrology Consult Letter Template, a new web-based tool to improve coordination of care for kidney patients for Chronic Kidney Disease.
- "Imagination" Helps Older People Remember to Comply with Medical Advice
A healthy dose of "imagination" helps older people remember to take medications and follow other medical advice, according to a new study supported by the National Institute on Aging (NIA), a part of the National Institutes of Health.
- Fibroid Tumors Lack Crucial Structural Protein
Researchers have discovered that fibroids have low levels of the protein dermatopontin.
- RNAi delivery system crosses blood-brain barrier to target brain cancer
Researchers have combined novel molecular targeting technologies to deliver gene-silencing therapy specifically to tumor cells shielded by a normally impermeable obstacle, the blood brain barrier.
- "Noisy" Genes Can Have Big Impact
Can randomness in gene expression lead to differences in cells that are genetically identical?
- Developing Tools for Reliable "Gene Chip" Measurements
Metrology and Standards Needs for Gene Expression Technologies: Universal RNA Standards
- Blocking Brain Masculinization With Aspirin
Research paper reports that drugs like aspirin that block the synthesis of testosterone can interfere with brain masculinization and later male sexual behavior in rats.
- A Placebo Response In The Brain
Sometimes just pretending to give a drug can alleviate the symptoms of Parkinson's disease, as long as the patient believes that the treatment is effective.
- Prion Proteins In The Human Food Chain
A new study reports that Prion proteins can be found in the muscles of infected sheep.
- Antidepressant Takes The Gloom Off Spinal Injury
The antidepressant rolipram help rats recover from spinal cord injury.

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