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  March 22, 2018
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- Layered Immunologic Memory
Distinct populations of antibody-producing memory immune cells arise due to vaccination.
- Possible Multiple Sclerosis Biomarker
Small molecules of RNA are positively associated with disease relapses in multiple sclerosis (MS) in patients according to a report published online.
- Age-Related Sperm Mutations Associated with Testicular Tumor
A rare type of benign testicular tumor is associated with genetic mutations arising from paternal age-effect mutations, which are inherited from fathers that are older than the population mean.
- A Genetic Region Implicated in Schizophrenia
Duplications of a given DNA sequence on chromosome 16 are associated with schizophrenia.
- CRLF2 Defects in Down Syndrome-Associated Leukemia
A chromosomal alteration that fuses the P2RY8 and CRLF2 genes is found in individuals with B-progenitor acute lymphoblastic leukemia (ALL) and ALL associated with Down syndrome (DS).
- Variants Associated with Systemic Lupus Erythematosus
Twelve new genetic variants are associated with increased risk of systemic lupus erythematosus (SLE), according to 2 independent studies published online.
- Ribosome Reactions
Two studies discuss new fundamental properties of the ribosome as well as new ways to manipulate the ribosomal machinery.
- Intravital Imaging Reveals Regulation of Metastasis
Activation of a specific intracellular signalling cascade determines whether cancer cells spread as single cells or as a collective unit, and whether they invade via the lymph system or blood.
- Stem Cells Help Study of Infertility Genes
Researchers have tracked and isolated germ cells derived from human embryonic stem cells and studied which genes are involved in their formation.
- Synapse, So What?
Study shows that certain neurons can exert their inhibitory effects without using the specialized intercellular junctions.
- Cancer Link to Microenvironment
A key signalling pathway that operates in mammary gland connective tissue cells helps to suppress the development of mammary tumours.
- Signalling Pathway Link to Cancer
The NF-kappaB signalling pathway has a vital role in certain cancers
- Repairing Memory after a Sleepless Night
The cognitive deficits caused by sleep deprivation may be reversible by reducing the concentration of a specific enzyme in the hippocampus of the brain.
- Gene Wiki: A community-based approach for human gene annotation
A recent paper describes the advances of a public online resource for human gene annotation
- Juggling with White Matter
Learning a complex task, such as juggling, which involves visual and movement processes results in changes in the connective white matter in the brain.
- Variants Associated with Blood Cell Traits
Thirty-four new genetic regions are associated with blood cell traits, according to four independent studies published online.
- Genomic Privacy and Detecting Participation in Genetic Research
A new study reports an improved method to infer an individual's membership in experimental datasets, and suggests increased restrictions may be needed.
- Reprogramming Gene Plays a Role in Cancer
The gene SOX2 is activated in lung and esophageal squamous cell carcinomas (SCC).
- Variants Associated With Bone Mineral Density
Thirteen new genetic loci are associated with bone mineral density.
- An Atomic View of the Ribosome
Nobel Laureate Ramakrishnan and his colleague summarise what studies of the structure and function of the ribosome have revealed and their hopes for the future.
- Protein Link to Long Life
The mitochondrial protein complex prohibitin promotes longevity in the nematode worm Caenorhabditis elegans by influencing fat metabolism.
- Where is the Heritability?
A review article asks what strategies should be explored to illuminate the genetics of complex diseases, and examines potential sources of missing heritability.
- Scanning and Linking For Autism
A double-pronged approach to uncovering genetic variants involved in autism is published.
- Mapping Diversity
A working map of regions of genetic variation across the human genome is reported online.
- A Personalized Medicine Research Agenda
Scientist group found the raw DNA data of direct-to-consumer genetic tests performed by two companies to be accurate, but they spotted inconsistencies between the two companies' disease-risk predictions.
- Breast Cancer Evolution
The genetic evolution of a breast tumour is reported.
- The Systems Biology Graphical Notation
A recent paper describes unified languages for molecular systems biology
- Clusterin Suppresses Prostate Cancer in Mice
A molecule that keeps prostate cancer at bay in mice is reported online.
- Regulating Stem Cell Treatments
Patients with incurable diseases are increasingly travelling thousands of miles for expensive, but risky and unproven stem-cell procedures.
- Regaining Running in Paralyzed Rats
A complex combination of drugs, electrical stimulation and regular exercise can enable paralyzed rats to walk and even run on a treadmill.
- While You Were Sleeping
Patients in vegetative and minimally conscious states still appear capable of acquiring certain forms of learning.
- Lung Cancer in a Breath
A sensor made up of gold nanoparticles can distinguish the breath of lung-cancer patients from healthy individuals in a high-humidity atmosphere.
- Silence, Please!
A new formulation of magnetic nanoparticles used to deliver nucleic acids that slow tumour progression in mice is reported.
- Preserving Fertility during Cancer Treatment
A mechanism that accounts for the negative effects of chemotherapy on female fertility, and a potential way to prevent it with a well known drug, is reported.
- Losing Weight without Too Much Energy
A pathway for how insulin signaling in the mouse hypothamalus -- a region of the brain known to control food intake -- is involved in obesity is presented.
- Driving Autoreactive Cells to Distraction
How potentially autoreactive T cells are prevented from being 'switched on' is reported in a paper published online.
- Variants in Prostate Cancer
New genetic variants that are associated with increased risk of prostate cancer have been identified in four studies published online.
- Direct RNA Sequencing
A new technique that enables researchers to sequence RNA directly should boost our understanding of human biology and disease.
- Ancient Roots for India's Rich Diversity
Current distinctions among groups within the Indian subcontinent are ancient, and strong inbreeding must have shaped marriage patterns in India for thousands of years.
- Itching to Quit
Nicotine activates a channel known to be involved in inflammatory responses.
- Channels for Stroke Treatment
Nerve cell death and memory deficits in a rat model of stroke can be prevented by the suppression of a certain ion channel.
- Hepatitis C Treatment Response
Genetic variation in an interferon gene is associated with treatment response in individuals with chronic hepatitis C virus (HCV).
- Susceptibility to ALS
Two new genetic associations to amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, are reported.
- Three New Targets in Alzheimer's Disease
Three new genetic associations to late onset Alzheimer's disease are reported in two papers.
- Holding Off HIV
Scientists have discovered a new strategy to inhibit HIV entry into host cells.
- Small Drug Blocks Cancer-Related Pathway
A small molecule that blocks the activity of a signalling pathway implicated in many cancers is revealed.
- Colourful Gene Therapy
Researchers have given colour-blind monkeys the ability to see in full colour.
- A Prostate Stem Cell Linked to Cancer
Prostate cancer could be caused by the aberrant activity of a newly identified stem cell type.
- Computational Tools for SNP-based Homozygosity Mapping
Several freely available tools for SNP-based homozygosity mapping of recessive disorders are described
- Blocking Out Negativity
How people process the social stigma of having visible skin lesions is reported.

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