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  October 16, 2018
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2009-11-02
- Layered Immunologic Memory
Distinct populations of antibody-producing memory immune cells arise due to vaccination.
- Possible Multiple Sclerosis Biomarker
Small molecules of RNA are positively associated with disease relapses in multiple sclerosis (MS) in patients according to a report published online.
- Age-Related Sperm Mutations Associated with Testicular Tumor
A rare type of benign testicular tumor is associated with genetic mutations arising from paternal age-effect mutations, which are inherited from fathers that are older than the population mean.
- A Genetic Region Implicated in Schizophrenia
Duplications of a given DNA sequence on chromosome 16 are associated with schizophrenia.
- CRLF2 Defects in Down Syndrome-Associated Leukemia
A chromosomal alteration that fuses the P2RY8 and CRLF2 genes is found in individuals with B-progenitor acute lymphoblastic leukemia (ALL) and ALL associated with Down syndrome (DS).
- Variants Associated with Systemic Lupus Erythematosus
Twelve new genetic variants are associated with increased risk of systemic lupus erythematosus (SLE), according to 2 independent studies published online.
- Ribosome Reactions
Two studies discuss new fundamental properties of the ribosome as well as new ways to manipulate the ribosomal machinery.
- Intravital Imaging Reveals Regulation of Metastasis
Activation of a specific intracellular signalling cascade determines whether cancer cells spread as single cells or as a collective unit, and whether they invade via the lymph system or blood.
- Stem Cells Help Study of Infertility Genes
Researchers have tracked and isolated germ cells derived from human embryonic stem cells and studied which genes are involved in their formation.
- Synapse, So What?
Study shows that certain neurons can exert their inhibitory effects without using the specialized intercellular junctions.
- Cancer Link to Microenvironment
A key signalling pathway that operates in mammary gland connective tissue cells helps to suppress the development of mammary tumours.
- Signalling Pathway Link to Cancer
The NF-kappaB signalling pathway has a vital role in certain cancers
- Repairing Memory after a Sleepless Night
The cognitive deficits caused by sleep deprivation may be reversible by reducing the concentration of a specific enzyme in the hippocampus of the brain.
2009-10-16
- Gene Wiki: A community-based approach for human gene annotation
A recent paper describes the advances of a public online resource for human gene annotation
- Juggling with White Matter
Learning a complex task, such as juggling, which involves visual and movement processes results in changes in the connective white matter in the brain.
- Variants Associated with Blood Cell Traits
Thirty-four new genetic regions are associated with blood cell traits, according to four independent studies published online.
- Genomic Privacy and Detecting Participation in Genetic Research
A new study reports an improved method to infer an individual's membership in experimental datasets, and suggests increased restrictions may be needed.
- Reprogramming Gene Plays a Role in Cancer
The gene SOX2 is activated in lung and esophageal squamous cell carcinomas (SCC).
- Variants Associated With Bone Mineral Density
Thirteen new genetic loci are associated with bone mineral density.
- An Atomic View of the Ribosome
Nobel Laureate Ramakrishnan and his colleague summarise what studies of the structure and function of the ribosome have revealed and their hopes for the future.
- Protein Link to Long Life
The mitochondrial protein complex prohibitin promotes longevity in the nematode worm Caenorhabditis elegans by influencing fat metabolism.
- Where is the Heritability?
A review article asks what strategies should be explored to illuminate the genetics of complex diseases, and examines potential sources of missing heritability.
- Scanning and Linking For Autism
A double-pronged approach to uncovering genetic variants involved in autism is published.
- Mapping Diversity
A working map of regions of genetic variation across the human genome is reported online.
- A Personalized Medicine Research Agenda
Scientist group found the raw DNA data of direct-to-consumer genetic tests performed by two companies to be accurate, but they spotted inconsistencies between the two companies' disease-risk predictions.
- Breast Cancer Evolution
The genetic evolution of a breast tumour is reported.
2009-10-02
- The Systems Biology Graphical Notation
A recent paper describes unified languages for molecular systems biology
2009-10-01
- Clusterin Suppresses Prostate Cancer in Mice
A molecule that keeps prostate cancer at bay in mice is reported online.
- Regulating Stem Cell Treatments
Patients with incurable diseases are increasingly travelling thousands of miles for expensive, but risky and unproven stem-cell procedures.
- Regaining Running in Paralyzed Rats
A complex combination of drugs, electrical stimulation and regular exercise can enable paralyzed rats to walk and even run on a treadmill.
- While You Were Sleeping
Patients in vegetative and minimally conscious states still appear capable of acquiring certain forms of learning.
- Lung Cancer in a Breath
A sensor made up of gold nanoparticles can distinguish the breath of lung-cancer patients from healthy individuals in a high-humidity atmosphere.
- Silence, Please!
A new formulation of magnetic nanoparticles used to deliver nucleic acids that slow tumour progression in mice is reported.
- Preserving Fertility during Cancer Treatment
A mechanism that accounts for the negative effects of chemotherapy on female fertility, and a potential way to prevent it with a well known drug, is reported.
- Losing Weight without Too Much Energy
A pathway for how insulin signaling in the mouse hypothamalus -- a region of the brain known to control food intake -- is involved in obesity is presented.
- Driving Autoreactive Cells to Distraction
How potentially autoreactive T cells are prevented from being 'switched on' is reported in a paper published online.
- Variants in Prostate Cancer
New genetic variants that are associated with increased risk of prostate cancer have been identified in four studies published online.
- Direct RNA Sequencing
A new technique that enables researchers to sequence RNA directly should boost our understanding of human biology and disease.
- Ancient Roots for India's Rich Diversity
Current distinctions among groups within the Indian subcontinent are ancient, and strong inbreeding must have shaped marriage patterns in India for thousands of years.
2009-09-17
- Itching to Quit
Nicotine activates a channel known to be involved in inflammatory responses.
- Channels for Stroke Treatment
Nerve cell death and memory deficits in a rat model of stroke can be prevented by the suppression of a certain ion channel.
- Hepatitis C Treatment Response
Genetic variation in an interferon gene is associated with treatment response in individuals with chronic hepatitis C virus (HCV).
- Susceptibility to ALS
Two new genetic associations to amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, are reported.
- Three New Targets in Alzheimer's Disease
Three new genetic associations to late onset Alzheimer's disease are reported in two papers.
- Holding Off HIV
Scientists have discovered a new strategy to inhibit HIV entry into host cells.
- Small Drug Blocks Cancer-Related Pathway
A small molecule that blocks the activity of a signalling pathway implicated in many cancers is revealed.
- Colourful Gene Therapy
Researchers have given colour-blind monkeys the ability to see in full colour.
- A Prostate Stem Cell Linked to Cancer
Prostate cancer could be caused by the aberrant activity of a newly identified stem cell type.
2009-09-04
- Computational Tools for SNP-based Homozygosity Mapping
Several freely available tools for SNP-based homozygosity mapping of recessive disorders are described
2009-08-27
- Blocking Out Negativity
How people process the social stigma of having visible skin lesions is reported.


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