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  May 20, 2024
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- TBK1 Is Doubly Important
Research demonstrates how DNA vaccines may induce adaptive immune responses.
- The Plaque To Dementia
Recent questions as to the role of amyloid plaques in the brains of patients with Alzheimer's disease are addressed.
- Circadian Rhythms
The release of blood stem cells into the bloodstream is regulated by circadian rhythms.
- Controlling A Double-Edged Sword
Two papers offer valuable insight into how the key protein, known as SIRT1, is regulated.
- DNA Blueprint For Crystallization
Two papers describe the programming of encodable interactions between nanoscale building blocks achieved by exploiting the recognition capabilities of DNA base pairing to direct assembly.
- Sugar Rush To Protect The Heart
Research uncovers an emergency strategy that the heart muscle uses to protect itself under such circumstances - enlisting molecules that help to keep it supplied with vital energy.
- New Cells' Effect On Learning
The deletion of a protein required for the proliferation of adult neural stem cells in mice appears to affect spatial learning and memory.
- Depression Relinquishes Secrets To Imaging
Functional imaging distinguishes between geriatric patients who respond to antidepressant drug therapy and those who do not.
- Sleep Provides A Window Into Memory
Patterns of brain activity while awake can shape the formation of their neuron connections during sleep.
- A Stem Cell-Based Therapy To Treat Muscular Dystrophy
A new way to manipulate embryonic stem cells (ESCs) in mice offers hope for an eventual cell-based therapy to treat muscular dystrophies, suggests a paper online.
- To Mend A Failing Heart
A method to create an artificial heart using the remains of an actual full-sized adult heart that has been stripped of all its cells, but then replanted with neonatal heart cells, may hold promise for its eventual use in transplant surgery.
- Seeing How Viruses Encounter Immune Cells
Study uncovers a surprising answer that may help to create effective anti-viral vaccines.
- Genetic Variants Associated With Susceptibility To Lupus
Newly discovered genetic variants in at least six different regions of the genome are associated with increased risk of developing lupus.
- Genetics Of Height And Bone Disease
Variants on a genetic locus related to osteoarthritis also affect the height of an individual, according to research.
- Seven Novel Loci For Plasma Lipid Levels
Three new genome-wide association studies report seven novel genes or loci associated with lipid levels.
- Receptor Signalling In Pairs
Scientists have discovered new information about the way that small molecules cause cell signalling.
- Transmitting HIV Through T Cell Nanotubes
Membrane nanotubes formed by contact between immune T-cells significantly increase transmission efficiency of HIV between infected and uninfected cells.
- RNA And Tumour Suppression
Researchers identify a candidate tumour suppressor gene for the deletions on chromosome 5q that are associated with certain blood-cell-production diseases.
- Identifying Skin Cancer Starter Cells
Cells that initiate human skin cancer are identified.
- Tethering HIV
An antiviral molecule called a 'tetherin' that acts to inhibit HIV-1 particle release from cells is identified.
- Suppressing A Leukaemia Suppressor
The expression of genes that help to limit the growth of normal cells can sometimes be turned down in cancer, causing cells to divide uncontrollably - hence their branding as 'tumour suppressor' genes.
- MicroRNAs That Reduce Metastasis
Restoring the expression of certain microRNAs (miRNAs) that are lost as breast cancer starts to metastasize suppresses the spread of the cancer
- A triggering event is identified in the transformation of a precancerous cell to a cancer stem cell
A study of monochorionic twins attributes the transformation of a preleukemic cell to a leukemic stem cell to the formation of a fusion gene, TEL-AML1.
- Identification of a Novel Neural Stem Cell Type
Neural rosette cells have the potential to form all cell types found in the mammalian nervous system
- Molecular Evolution of Limb Length
Changes in gene expression can create inter-species variation
- The Protective Effects of Brain Damage
Combat veterans with certain types of brain damage are less likely to develop post-traumatic stress disorder (PTSD).
- A Pathway Controlling Body Temperature
Scientists have identified neurons that relay temperature information from sensory fibres in the spinal cord to the thermoregulatory control centre in the brain.
- Walking After Spinal Rewiring
Rewiring of nerve fibres in the spinal cord helps mice to regain the ability to walk after injury.
- Foamy Viruses Join The Gene Therapy Toolbox
Foamy virus vectors have been used to cure a genetic immune deficiency in dogs.
- The Workings Of Deep Brain Stimulation
A chemical called adenosine plays a key role in the beneficial effect of deep brain stimulation on tremor.
- First Sign Of Trouble
Expression of a single stress response protein, even in the absence of 'danger' signals displayed by invading microbes or dying cells, triggers massive reorganization and activation of immune cells.
- Gaining Entry Into The Brain
Researchers have identified a protein used by aggressive immune cells seeking to breach the blood-brain barrier.
- Gene Mutation Affecting Human Brain Size
Scientists have identified mutations in a gene that cause reduced brain and body size.
- Genetic Susceptibility To Kawasaki Disease
A variant in a gene called ITPKC is associated with increased susceptibility to Kawasaki disease.
- Genetic Risk Factor For ALS
Scientists have identified a variant in the gene DPP6 that increases susceptibility to amyotrophic lateral sclerosis (ALS).
- Control of EGFR in Breast Cancer Cell Invasion
A mechanism explaining how epidermal growth factor (EGF) regulates breast cancer cell invasion is published.
- Breast Cancer Goes NUMB
A protein called NUMB has a crucial role in keeping breast cancer at bay.
- When Three Is Better Than Two
People with Down's syndrome seem to be less susceptible to cancers - an observation that may at least partly derive from their having an extra copy of the chromosome responsible for the syndrome, chromosome 21.
- A New Role For Nanog
Nanog safeguards the pluripotent state of embryonic stem cells, resetting them if they start to differentiate when they shouldn't.
- Looking For Cancer In All The Right Places
Viable tumour-derived epithelial cells (also known as circulating tumour cells or CTCs) have been identified in the blood of cancer patients.
- Brain Cells Are Smarter Than You Think
Individual brain cells can make a bigger contribution to behaviour and are capable of more computations than previously thought.
- Chemokine receptor CX3CR1 plays a central role in mediating skin wound healing
The chemokine receptor CX3CR1, which has been implicated in a number of inflammatory diseases, is also a key participant in the complex process of wound healing.
- Oligouridylation-mediated Histone mRNA Decay
Addition of uridines is a newly discovered component of mRNA regulation
- Making Sense of Antisense microRNAs
Newly described miRNAs transcribed from sense and antisense strands generates regulatory diversity
- You Must Remember This
A part of the brain known as the basal ganglia may act to filter out irrelevant information from memory, increasing its apparent capacity.
- A Mechanical Test For Cancer
Cancer cells are softer than healthy cells, according to mechanical measurements published online.
- Passive Immunotherapy Against Hepatitis C
Delivering antibodies that recognize the hepatitis C virus (HCV) can be therapeutically beneficial in a mouse model.
- Run Away From Your Depression
Scientists have discovered a molecule with antidepressant actions, which is produced by the brain as a result of physical exercise.
- Bad To The Bone
A drug commonly prescribed to diabetes patients may have negative effects on the bone.
- Restoring Bacterial Killing In Cystic Fibrosis
A report published online reveals that high protease levels in the lungs of patients with cystic fibrosis disable immune cells, explaining why CF patients fail to clear lung infections.

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