| 2006-11-13 |
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Molecular Regulator for Blood Flow Found in Mice
Thrombospondin-1 (TSP-1), a multifunctional protein involved in the nitric oxide-signaling pathway and is found to be part of the mechanism which restricts angiogenesis.
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| 2006-11-09 |
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Retinal transplants may help restore sight
British scientists have discovered non-dividing retinal cells implanted into adult mouse retina can generate new photoreceptors
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Genetic Risk For Schizophrenia And Brain Function
Variation in a gene linked with schizophrenia is associated with the occurrence of psychotic symptoms and cognitive deficits, along with reduced activity in the frontal and temporal lobes of the brain.
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Redefining Receptor Organization - Again
Serious doubt is cast on widely accepted models of how a crucial class of cell surface receptors organizes itself.
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Knocking Out False Positives In Interaction Proteomics
A new method for identifying, with very high confidence, cellular proteins that naturally interact with each other is described.
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A Potential Male Contraceptive
Scientists report that it is possible to induce infertility in rats by specifically targeting germ cell adhesion in the testis.
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Benefits Of Fever
Developing a fever gives the immune system a boost.
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Kidney Disease Caused By Mutation May Be Reversible
The identification of a new genetic cause of a damaging kidney disease, nephrotic syndrome, is reported.
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Small RNAs Drive Evolution
Scientists report new evidence supporting the importance of a class of small RNA molecules in human evolution.
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Towards A Complete Human 'Epigenome'
The DNA methylation profile of three human chromosomes is reported.
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New Sonic Hedgehog Receptor
A new receptor for the sonic hedgehog protein, that helps control nerve growth, is described in a report published online.
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Drug Duo Could Combat Retinal Cancers
Researchers provide evidence implicating inactivation of the tumour suppressor gene p53 in retinoblastoma.
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DNA Degradation Link To Rheumatoid Arthritis
A failure to degrade DNA properly may contribute to the development of rheumatoid arthritis.
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Gene Therapy By Membrane-Expressed Superantigen For Alpha-Fetoprotein-Producing Hepatocellular Carcinoma
Research findings suggest that membrane-expressed Staphylococcus enterotoxin A (SEA) by adenovirus can generate stronger local and systemic antitumor responses against Hepatocellular Carcinoma.
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Antisense Smo Under The Control Of The PTCH1 Promoter Delivered By An Adenoviral Vector Inhibits The Growth Of Human Pancreatic Cancer
Researchers develop a cell-specific cytotoxic model for the treatment of human pancreatic cancer.
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X PRIZE for Genomics Launched
$10 Million Archon X PRIZE for Genomics Challenges Private Companies to Map 100 Human Genomes in 10 Days
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| 2006-11-08 |
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Elucidation of NF-kB’s Involvement In Muscle Homeostasis
Disruption of NF-kB signaling improves muscle physiology, protects against atrophy, and enhances regeneration following injury.
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| 2006-11-06 |
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Sudden Infant Death Syndrome May Be Linked to Areas in the Brain Controlling Breathing and Heart Rate
Brainstem and serotonin implicated in abnormalities.
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Staph Vaccine Shows Promise in Mouse Study
Vaccine offers hope for a bacteria which has become antibiotic resistant and more virulent in the recent past.
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Honey Bee Genome Analyzed
Honey Bee genome is more similar to humans than any insect sequenced thus far.
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| 2006-11-01 |
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A Friend from A Foe: Parasite Helps Reverse Human Mitochondrial Defect
Parasite protein complex transports corrective RNAs in diseased human cells.
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| 2006-10-27 |
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Caveat mTOR: PML in the repression of the angiogenic switch
The product of the tumor-suppressor gene promyelocytic leukemia (PML) has been found to be a crucial inhibitor of neo-angiogenesis, in both neoplastic and ischemic conditions.
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Laser Traps Shed Light On Infection Defenses
A new technology that mimics the suspension of white blood cells in blood in the body is reported.
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Towards Better Anti-Epileptic Drugs
A completely new way of suppressing epileptic seizures in rats is reported in a study.
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TAPping Into Mammalian Interaction Proteomics
A new method enabling the efficient isolation of protein complexes from mammalian cells is described.
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Bittersweet News For Neural Stem Cell Grafts
Using human embryonic stem - HES - cells directed to a neural fate to treat Parkinson's disease might be more complicated than previously thought.
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Protecting Mothers From Fetal Immune Recognition
A protein expressed in developing embryos may protect mothers against immune-mediated attack by fetal cells.
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New Sex Determination Gene Identified
Mutations in a gene called RSPO1 result in female to male sex reversal.
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Insulin-Producing Cells From Human Embryonic Stem Cells
The culture conditions under which human embryonic stem cells can be converted into cells that produce all five hormones made by the pancreas, including insulin, are reported.
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Inducing Connections Between Brain Sites Alters Motor Function
Artificially connecting the activity of two brain sites can alter the motor function of freely behaving monkeys.
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Protein For Optical Clarity
The presence of a protein called soluble VEGF receptor-1 (sVEGFR-1) maintains optical clarity by keeping the cornea free of blood vessels.
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Cancer Stem Cells Resist Radiotherapy
Researchers now think they know why Glioblastomas (malignant brain tumours) very often recur after radiation therapy.
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| 2006-10-23 |
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Gene Linked to Autism
In families with more than one autistic child, the MET receptor tyrosine kinase gene on chromosome 7 may be responsible.
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Experimental Vaccine Protects Mice Against Deadly 1918 Flu Virus
Influenza virus is vulnerable to intervention.
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Preschoolers with ADHD Improve with Low Doses of Medication
Preschool ADHD Treatment Study shows that Ritalin in low doses is effective and safe.
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| 2006-10-17 |
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A Means to the Ends: Telomerase RNA Restores Telomere Length in Dyskeratosis Congenita
Telomerase RNA levels are involved in telomere shortening in X-linked dyskeratosis congenita
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Antipsychotic Medications Same As Placebo For Alzheimer’s Patients
First phase of a large-scale clinical trial demonstrates that while some Alzheimer's Patients can benefit from antipsychotic medications, most do not.
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Misfolded Protein Clumps Common in Lou Gehrig’s Disease
Researchers discover misfolded protein TDP-43 as a constituent part of the clumps that form in dementia providing new insights into the pathogenesis of neurological disorders.
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A Gene Mutation May Control Sensitivity to Alcohol
Fruit fly study identifies mutation in white rabbit gene that regulates sensitivity to alcohol.
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Ragweed Allergy Sufferers Can Benefit From Experimental Therapy
An experimental ragweed allergen immunotherapy shortens the time required to treat symptoms.
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A Link Between Cyclic Nucleotide Metabolism And Depression
Genetic variants of phosphodiesterase 11 are associated with the diagnosis of depression and with patient responsiveness to antidepressant therapy.
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| 2006-10-13 |
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Detecting Disease-Causing Mutations in the Human Genome by Haplotype Matching
The authors describe a new strategy for detecting mutations that is based on comparing affected haplotypes with closely matched control sequences from healthy individuals, rather than with the human reference genome.
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PLA2G6 Mutation Underlies Infantile Neuroaxonal Dystrophy
The study findings highlight a role of phospholipase in neurodegenerative disorders.
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A Novel Mutation in FGFR3 Causes Camptodactyly, Tall Stature, and Hearing Loss (CATSHL) Syndrome
Abnormal FGFR3 signaling can cause human anomalies by promoting as well as inhibiting endochondral bone growth.
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Systems Biology Tackles The Mechanisms Of Cancer
Potential novel targets for anti-cancer therapy are revealed.
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Itching And Scratching
Dust mites produce an allergen that disrupts the skin's ability to act as a barrier to other allergens and environmental irritants.
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Recommendations Help Identify Patients Suitable For NSAID Treatment
Recommendations should help physicians to identify quickly whether or not a patient is suitable for treatment with nonsteroidal anti-inflammatory drugs (NSAIDs).
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Focus On Childhood Developmental Disorders
A special focus issue on childhood developmental disorders, including specific language impairment and dyslexia, autism, and the mental retardation syndrome fragile X, is presented.
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New Strategy For Controlling Inflammation
A previously unknown method of terminating immune responses is reported.
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New Breast Cancer Susceptibility Gene Identified
Women with mutations in a gene called BRIP1 have twice the normal risk of breast cancer.
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