| 2006-04-12 |
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Metastasis Blocked
An international research team has identified what may be a pivotal molecule in the ability of tumours to metastasize - or spread - into bone.
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Targeting Leukaemia Stem Cells
Scientists study a tumour suppressor protein frequently inactivated in leukaemia and other cancers.
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Identifying The CRAC In Immunity
A key protein involved in triggering the immune response against pathogens is described.
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| 2006-04-11 |
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H5N1 Avian Flu Virus Vaccine Induces Immune Responses in Healthy Adults
Clinical trial reports that healthy adults can mount immune responses to high doses of H5N1 avian flu vaccine.
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RNA Interference Identifies New Targets for Cancer Therapies
Loss-of-function RNA interference genetic screen used to identify three genes not previously linked to cancer.
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High IQ Promotes Cortex Maturation in Youth
People with higher IQs do not have larger brains, but differences in brain development.
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| 2006-04-10 |
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Obsessive-Compulsive Disorder: A Gene Variant Linked to Risk
NIH Researchers find a gene variant that doubles an individual's risk for obsessive-compulsive disorder.
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| 2006-04-05 |
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A Nano Approach To Nerve Regeneration
A self-assembling peptide nanofiber scaffold supported nerve regeneration and return of function, after a surgical insult.
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| 2006-03-29 |
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Challenging the Strategy of Maternal Age-Based Prenatal Genetic Counseling
Article discusses the effect of current knowledge on the strategy of Maternal Age-Based Prenatal Genetic Counseling.
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Stretch Marks Are Never Good
Stretch marks are not only unsightly, but women with this disorder, appear to be at increased risk for pelvic prolapse.
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Getting Streptavidin To Go It Alone
Research describes a popular system for protein labelling and modification to reduce the risk of unwanted cross-reactions.
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A New Way To Spotlight Cells In Live Animals
Stanford University scientists have modified a popular strategy for imaging studies in live animals.
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Flu Killers
Researchers identify a key molecule required for surviving flu infections.
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Genetic Variants Associated With Common Skin Disorders
Mutations in a gene called filaggrin are associated with elevated risks of atopic disease.
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Generating Egg-Like Cells From Pig Fetal Skin
Stem cells isolated from the skin of pig fetuses are capable of giving rise to egg-like cells.
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The RNAi Revolution Marches On
Scientists have taken an important step towards a new class of drug treatment that harnesses the RNA interference pathway.
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Early Sign Of Alzheimer's
Scientists reveal what could be one of the earliest molecular seeds of Alzheimer's disease.
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Down's Syndrome
Scientists make an important step towards determining how a 1.5-fold increase in gene dosage on chromosome 21 triggers the various developmental problems associated with Down's syndrome.
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Alzheimer's Protein Player Exposed
Researchers reveal how an enzyme called Pin1 plays a part in the pathogenesis of Alzheimer's disease.
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'Accelerated Evolution' Converts RNA Enzyme To DNA Enzyme In Vitro
This "evolutionary conversion" provides a modern-day snapshot of how life as we understand it may have first evolved out of the earliest primordial mix of RNA-like molecules
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Study Analyzes Gene Therapy For Patients At High Risk For Amputation
TALISMAN (Therapeutic Angiogenesis Leg Ischemia Study for the Management of Arteriopathy and Non-healing ulcers) presented at ACC.06
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Minor Mutations in Avian Flu Virus Increase Chances of Human Infection
Few Adaptations Are Needed to Transform It into a Potential Pandemic Virus
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New View Of Asthma's Cause
Previously Unrecognized Immune Cell May Provide A Better Target For Therapy
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| 2006-03-28 |
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Support for a New Theory on the Etiology of Multiple Sclerosis
A reduction in the net positive charge on myelin basic protein reduces oligodendrocyte membrane adhesion and exposes an immunodominant epitope in the protein to proteases.
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| 2006-03-27 |
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A tale of a tail: to condense or not to condense....Ac is the question.
It has long been known that acetylation of core histone tails is fundamental in the organisation of a transcriptionally permissive chromatin structure. New work shows how this small modification has macromolecular effects.
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| 2006-03-24 |
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FDA and the Critical Path Institute Announce Predictive Safety Testing Consortium
Consortium Will Share Tests to Understand Safety of Potential New Drugs Earlier
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| 2006-03-21 |
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Defective Immune System Response to Smallpox Vaccine Detailed in New Study
People with Eczema May Benefit From Finding
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Speeding Neuro-communications
Electrical impulses foster myelination of brain cells, speeding communications.
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New Diagnostic: A Unique Molecular Profile for Lung Cancer
microRNAS are a new class of diagnostic and prognotic tools to help predict tumor aggressiveness for lung cancer.
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A Boost for Customized Drugs: Antidepressant Response Depends On Genetics
Different versions of the serotonin 2A receptor gene are found to influence antidepressant response.
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| 2006-03-20 |
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Allelic Variation in Gene Expression is Common in the Human Genome
Analysis of allelic expression in human white blood cells highlights a high degree of variability and suggests that imprinting may be more common than is traditionally believed
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| 2006-03-15 |
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Partners In Crime
Scientists have defined the detailed architecture of an enzyme crucial for the replication of two major human viruses.
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Protein Teamwork Underlies Skeleton
Researchers show how mutations in two different proteins can cause osteopetrosis, a rare congenital human disorder.
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It's All In The Expression
Changes in the expression level of certain genes may underlie some of the fundamental differences between humans and chimpanzees.
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Coral Compound Blocks Viruses
A small molecule has been discovered in coral that can be used to block the replication of certain viruses.
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A Murine Model for Human Sepiapterin-Reductase Deficiency
The Sepiapterin reductase gene (SPR) is essential for homeostasis of tetrahydrobiopterin (BH4) and for the normal functions of BH4-dependent enzymes.
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Hemizygosity at the NCF1 Gene in Patients with Williams-Beuren Syndrome Decreases Their Risk of Hypertension
The loss of a functional copy of the NCF1 gene protects a proportion of patients with WBS against hypertension.
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Spread of an Inactive Form of Caspase-12 in Humans Is Due to Recent Positive Selection
The authors suggest that the inactive form of the human caspase-12 gene arose in Africa 100–500 thousand years ago.
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The Power to Detect Disease Associations with Mitochondrial DNA Haplogroups
Scientists used a simulation-based (Monte Carlo) permutation test to generate power curves for European mtDNA haplogroup studies.
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A model for studying cell plasticity in the embryonic microenvironment
Transplanted human metastatic melanoma cells resemble neural crest stem cells in the chick embryo.
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| 2006-03-13 |
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The irresistible sirene’s chant of needle-free insulins
Insulin analogs are conquering the insulin market, inhaled insulins are the next generation, and oral insulins might bypass other delivery technologies
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| 2006-03-10 |
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Potential Marker To Identify Sickle Cell Patients at High Risk of Complications
Enzyme lactate dehydrogenase (LDH) holds promise in patients with sickle cell disease as a marker for risk of complications, including early death.
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Genetic Variations in the Immune System Influence Diseases in Surprising New Ways
Variations in the Complement System have a way of influencing diseases such as age-related macular degeneration and cancer.
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Natalizumab: Proceed with Caution
Natalizumab used to treat multiple sclerosis, Crohn’s disease, and rheumatoid arthritis may or may not be linked to progressive multifocal leukoencephalopathy.
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| 2006-03-07 |
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Genetic Association Information Network launched
The NIH and Pfizer collaborate to unravel the genetic causes of common diseases over the next 3 years.
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| 2006-03-06 |
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Antibodies are the first wave of IGF-1R antagonists for cancer therapy
At least six fully human or humanized antibodies against insulin-like growth factor-1 receptor (IGF-1R) are in early clinical development or close to phase I
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Glutamate Receptors And Schizophrenia
Significant Association With Polymorphisms in the 5′ End of the N-Methyl-D-Aspartate Receptor Subunit Gene GRIN1
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| 2006-03-01 |
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Creatine and Minocycline Show Promise for Parkinson's Disease
Preliminary study shows that creatine and minocycline warrant further investigation for the treatment of Parkinson's Disease.
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Complement Proteins Promote Neuron Formation In The Brain
Proteins involved in inflammatory responses could help with brain regeneration after a stroke.
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Childhood Depression Linked To Asthma And Obesity
The authors investigated how many of the participants suffered from childhood depression and compared this with those who later became obese or developed asthma.
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