home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Yellow Card For RNA Interference

  June, 7 2006 12:12
your information resource in human molecular genetics
A study in the 25 May issue of Nature (Vol. 441, No. 7092, pp. 537-541) shows the yellow card to the use of RNA interference in medicine. Mark Kay and his colleagues show that the long-term expression of RNA fragments in mice can end up killing the animals.

In RNA interference, a tiny piece of RNA is added to cells and used to switch off a particular gene; there is great hope that this strategy could be used to treat human disease. The researchers show that a virus can deliver so-called 'short hairpin RNAs' (shRNAs) to mouse liver cells. But of the 49 shRNAs they delivered, 36 of them caused liver injury - with 23 ultimately causing death.

The researchers found that the shRNAs interfered with the function of endogenous liver microRNAs, probably by competing for a limited supply of certain cellular proteins required for processing small RNAs. On the positive side, the group also show that delivering weak doses of one shRNA molecule can combat hepatitis B virus, suggesting that the technique could still work if the RNA dose is carefully controlled.


Mark M A Kay (Stanford University, Stanford, CA, USA)
E-mail: markay@stanford.edu

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.