The 18 May 06 issue of Nature (Vol. 441, No. 7091, pp. 315-321) reports the finished DNA sequence of human chromosome 1 - the final human chromosome to be completed and published - along with a detailed annotation of its genes and other features, such as duplicated regions and single nucleotide polymorphisms (SNPs).
Chromosome 1 is the largest of the human chromosomes, containing approximately 8% of all human genetic information. It is packed with 3,141 genes and 991 pseudogenes, report Simon Gregory and his colleagues, making it one of the most gene-dense chromosomes in humans.
Over 350 human diseases are associated with alterations of chromosome 1, and its sequence should help track down those for which the corresponding genes remain unknown. Also, by searching for regions that vary between different populations around the world, the team has identified key spots where natural selection seems to be acting.
Simon Gregory (Duke University, Durham, NC, USA)
Don Powell (Press Officer, The Wellcome Trust Sanger Institute, Hinxton, UK)
(C) Nature press release.
Message posted by: Trevor M. D'Souza
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