Synaptic Amplifier of Inflammatory Pain in the Spinal Dorsal Horn
Ikeda, H., Stark, J., Fischer, H. Wagner, M., Drdla, R., Jager, T., and Sandkuhler, J. Science, 312, 1659-1662 (June 16, 2006).
An electrophysiological study revealed that low frequency stimulation of ascending pain fibers induces the formation of a synaptic amplifier in post-synaptic spinal cord neurons. The model closely resembles the characteristics of the hyperalgesia pathway in terms of the induction mechanism, neuron populations, pharmacological profile, and signal transduction pathways. The results suggest that long-term potentiation at the first synapse between nociceptive C-fibers and spinal lamina I neurons is the key mechanism underlying chronic pain.
This model should support further research into the molecular mechanisms behind inflammatory pain and approaches to ameliorating the condition.
Message posted by: Keith Markey
Bookmark and Share this page (what is this?)
Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.
Use the links below to share this article on the social bookmarking site of your choice.
Read more about social bookmarking at Wikipedia - Social Bookmarking
Variants Associated with Pediatric Allergic Disorder
Mutations in PHF6 Found in T-Cell Leukemia
Genetic Risk Variant for Urinary Bladder Cancer
Antibody Has Therapeutic Effect on Mice with ALS
Regulating P53 Activity in Cancer Cells
Anti-RNA Therapy Counters Breast Cancer Spread
Mitochondrial DNA Diversity
The Power of RNA Sequencing
‘Pro-Ageing' Therapy for Cancer?
Niche Genetics Influence Leukaemia
Molecular Biology: Clinical Promise for RNA Interference
Chemoprevention Cocktail for Colon Cancer
more news ...