home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Identification of a Model for Enhanced Pain Sensitivity

  June, 21 2006 4:47
your information resource in human molecular genetics
Synaptic Amplifier of Inflammatory Pain in the Spinal Dorsal Horn
Ikeda, H., Stark, J., Fischer, H. Wagner, M., Drdla, R., Jager, T., and Sandkuhler, J. Science, 312, 1659-1662 (June 16, 2006).

An electrophysiological study revealed that low frequency stimulation of ascending pain fibers induces the formation of a synaptic amplifier in post-synaptic spinal cord neurons. The model closely resembles the characteristics of the hyperalgesia pathway in terms of the induction mechanism, neuron populations, pharmacological profile, and signal transduction pathways. The results suggest that long-term potentiation at the first synapse between nociceptive C-fibers and spinal lamina I neurons is the key mechanism underlying chronic pain.

This model should support further research into the molecular mechanisms behind inflammatory pain and approaches to ameliorating the condition.

Message posted by: Keith Markey

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.