home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism

 
  June, 7 2006 12:33
your information resource in human molecular genetics
 
     
In a paper authored by Valérie Senée, Claude Chelala, Sabine Duchatelet, et al., and published in Nature Genetics (Vol. 38, pp. 682-687), a new neonatal diabetes syndrome associated with congenital hypothyroidism, congenital glaucoma, hepatic fibrosis and polycystic kidneys, is decribed. It is shown that this syndrome results from mutations in GLIS3, encoding GLI similar 3, a recently identified transcription factor.

These results demonstrate a major role for GLIS3 in the development of pancreatic cells and the thyroid, eye, liver and kidney.

Author Contact:

Cécile Julier
Institut Pasteur, Génétique des Maladies Infectieuses et Autoimmunes, 75015 Paris, France.
E-mail: cjulier@pasteur.fr

Abstract available online.

(C) Nature Genetics.

Posted by: Tressie Dalaya


Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.