Hodgson et al. (American Journal of Human Genetics) performed a genomewide scan in six multiplex families with familial idiopathic pulmonary fibrosis (IPF) who originated from southeastern Finland.
The majority of the Finnish multiplex families were clustered in the region, and the population history suggested that the clustering might be explained by an ancestor shared among the patients. The genomewide scan identified five loci of interest.
Their results suggest ELMOD2 as a novel candidate gene for susceptibility in familial IPF.
Ulla Hodgson, Department of Pulmonary Medicine, Helsinki University Central Hospital, Departments of Medical Genetics, University of Helsinki, Stockholm.
Tarja Laitinen, Department of Pulmonary Medicine, Helsinki University Central Hospital, Departments of Medical Genetics, University of Helsinki, Stockholm.
Abstract available online.
(C) American Journal of Human Genetics.
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