home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Gene Therapy Prevents The Onset Of Diabetic Symptoms In Mice

  June, 5 2006 19:59
your information resource in human molecular genetics
More than 700,000 Americans have type 1 diabetes, an autoimmune disorder in which the body errantly attacks the cells of the insulin-producing cells of the pancreas, causing chronic hyperglycemia and complications such as blindness, kidney failure, heart disease and nerve damage. Previously known as juvenile diabetes, type 1 diabetes is usually diagnosed at a very early age but is sometimes not diagnosed until the individual reaches adulthood.

In this study, the Pitt researchers used a gene-delivery vehicle known as an adeno-associated virus to insert genes for either of two cytokines, interleukin-4 (IL-4) or interleukin-10 (IL-10), into the insulin-producing beta cells of non-obese diabetic (NOD) mice. Following gene delivery, expression of IL-4 in beta cells prevented the onset of hyperglycemia in NOD mice, whereas beta cell expression of IL-10 accelerated the onset of hyperglycemia.

According to lead author Khaleel Rehman Khaja, Ph.D., senior research associate, department of molecular genetics and biochemistry, University of Pittsburgh School of Medicine, results from this animal study suggest that gene therapy is a viable method for preventing the onset of type 1 diabetes in genetically at-risk people.

"We know that the prevention of type 1 diabetes requires early intervention in the autoimmune process directed against beta cells of the pancreatic islets. Although the exact mechanism is still under investigation, we believe the protection we observed in our study is due to IL-4 stimulating an increase in regulatory T cells, which are known to suppress the activation of the immune system. However, the most important aspect of our study is that we've shown it is now possible to efficiently insert genes into beta cells in a living organism, allowing us to analyze the effects that different gene products have on the progression of type 1 diabetes," he explained.

Others involved in this study include Zhong Wang, Ph.D., Xiao Xiao, Ph.D., and Paul D. Robbins, Ph.D., departments of molecular genetics and biochemistry and orthopaedic surgery, University of Pittsburgh School of Medicine.

Message posted by: Simon Chandler

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.