home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Immune Molecule Fuels Tumours

  May, 24 2006 7:20
your information resource in human molecular genetics
A molecule central to chronic autoimmune diseases also promotes the incidence and growth of tumours, show Martin Oft and his colleagues in a study to be published online this week by Nature.

Doctors have suspected for more than a century that the inflammation associated with tumours also regulates their growth. Oft’s team find one such link: they show that interleukin-23 (IL-23), a cytokine already implicated in inflammatory bowel disease and other autoimmune disorders, is also central to cancer development.

The researchers show that many human tumours make excess IL-23. Blocking IL-23 in mice - using genetic engineering or an antibody - protects against carcinogens because protective T cells are better able to infiltrate transformed tissue and kill pre-cancerous cells. The results suggest that antibodies that block IL-23 might help these cytotoxic T cells invade and treat human tumours.


Martin Oft (Schering-Plough Biopharma, Palo Alto, CA, USA)
E-mail: martin.oft@spcorp.com

Abstract available online.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.