home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Cilia's Dual Role in Cancer

 
  August, 27 2009 19:26
your information resource in human molecular genetics
 
     

Cilia can promote or suppress tumor growth, depending on the nature of the tumor-initiating event, as reported by two studies in Nature Medicine.

Primary cilia are specialized appendages that extend from the surface of many cell types and have been implicated in cell signaling. They are crucial during fetal development for signaling pathways mediated by a protein known as Hedgehog. As Hedgehog has also been implicated in cancers, Jeremy Reiter, Arturo Alvarez-Buylla and their respective colleagues explored the possible contribution of primary cilia to tumor formation.

Studying two types of cancer, basal cell carcinoma and medulloblastoma, the two groups independently found that cilia could favor or inhibit tumor formation in mice. If the tumor was triggered by the expression of Smoothened, a well-known activator of Hedgehog, removal of cilia blocked tumor formation. But if the tumor was initiated by the expression of Gli2, a molecule downstream of Hedgehog, then removal of cilia accelerated tumor growth.

These data disclose an unexpected dual role of cilia on cancer. Further analysis of their role may lead to better understanding of tumor development and treatment.

Author Contacts:

Jeremy Reiter (University of California San Francisco, CA, USA)
E-mail: jeremy.reiter@ucsf.edu

Arturo Alvarez-Buylla (University of California San Francisco, CA, USA)
E-mail: abuylla@stemcell.ucsf.edu

Abstracts available online:

Paper 1 Abstract.
Paper 2 Abstract.

(C) Nature Medicine.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.