home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Preventing Diseases by Replacing Defective DNA

  August, 27 2009 19:14
your information resource in human molecular genetics

A new approach has been devised to replace defective mitochondrial DNA (mtDNA) from an egg with healthy mtDNA from a donor, is reported online in Nature. These findings may lead to new preventative therapeutic options for the numerous diseases transmitted through mtDNA.

Cellular mitochondria are crucial to many processes including energy production. However, whereas the nuclear DNA in cells is derived from a combination of both egg and sperm DNA, the mtDNA is almost exclusively from maternal DNA. There are presently over 150 different mtDNA defects known to cause incurable diseases.

Shoukhrat Mitalipov and colleagues devised a new approach to swap mtDNA in monkey eggs. This method involves removing the nuclear DNA from the egg of one monkey and inserting it into another monkey's egg where the nuclear DNA has been removed, but that retains its mtDNA. The reconstructed eggs produced using this method were successfully fertilized and produced three apparently healthy offspring. The scientists propose that this technique could be used to replace defective mitochondria in IVF procedures.


Shoukhrat Mitalipov (Oregon National Primate Research Center and Oregon Health & Science University, Beaverton, OR, USA)

Abstract available online.

(C) Nature  press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2021 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.