home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Chromosomes, Know Your Place

 
  July, 30 2009 7:11
your information resource in human molecular genetics
 
     

A catalogue of factors that help to keep the order of genes on chromosomes 'in their place' and so prevent genomic instability is revealed in Nature.

The human genome contains many types of repeated 'at risk' sequences that are inherently unstable and can undergo genomic rearrangements. The cell uses various proteins to ensure that such rearrangements do not occur often. Richard Kolodner and colleagues provide a comprehensive analysis of factors involved in suppressing large-scale chromosomal rearrangements.

They find, surprisingly, that these repetitive at-risk sequences use a pathway to suppress rearrangements that is distinct from that used to stabilize single-copy sequences. This study helps explain how genomes manage to remain stable despite containing many types of at-risk sequences.

CONTACT

Richard Kolodner (Ludwig Institute for Cancer Research, La Jolla, CA, USA)
E-mail: rkolodner@ucsd.edu

Abstract available online.

(C) Nature press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.