home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Cell Source Matters for In Vitro Bone Growth

  July, 30 2009 7:25
your information resource in human molecular genetics

The type of cell used to grow bone for tissue replacement in the lab makes a difference to the properties of the resulting material, researchers report online in Nature Materials. The finding highlights for the first time the need to also consider the source of cells when creating replacement tissues.

Laboratory-grown, implantable, cell-seeded materials that can be used to restore function are a major aim of regenerative medicine. Molly Stevens and colleagues show that the source of cells used to create those constructs needs to be carefully and systematically chosen to ensure therapeutic benefit.

The researchers grow bone from osteoblasts, adult stem cells, or embryonic stem cells, and show that the bone nodules that form from both osteoblasts and adult stem cells are consistent with native bone in terms of mineral composition, nanoscale architecture and gene expression. However, the bone grown from embryonic stem cells is more similar to mechanically compromised aged native bone than to healthy tissue.

Author contact:

Molly Stevens (Imperial College London, UK)
E-mail: m.stevens@imperial.ac.uk

Abstract available online.

(C) Nature Materials press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.