home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Hope for Hepatitis C Treatment

  August, 27 2009 19:04
your information resource in human molecular genetics
DNA sequence variation that affects a person's response to treatment for chronic infections by the hepatitis C virus is reported online in Nature. The findings represent the strongest study of predictors of treatment response to date, and may be of immediate clinical use in the development of a test for those considering treatment for hepatitis C.

Hepatitis C affects around 170 million people worldwide and is the leading cause of cirrhosis in the North America. Current treatments for the disease, which involve targeting proteins in the immune system, are difficult, time consuming, and quite often ineffective. David Goldstein and colleagues use a genome-wide association study to show that DNA sequence variations near the gene IL28B are associated with a significant change in the levels of treatment response when comparing European and African-American patients.

Because the variant associated with better treatment response was found to be more common in those of European decent compared to those of African origin it helps to explain why there is such a large difference in the effectiveness of treatment of the disease between these two populations of sufferers.

Author contact:

David Goldstein (Duke University, Durham, NC, USA)
E-mail: d.goldstein@duke.edu

Abstract available online.

(C) Nature  press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2021 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.