home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

Silence, Please!

 
  August, 27 2009 19:36
your information resource in human molecular genetics
 
     

A new formulation of magnetic nanoparticles used to deliver nucleic acids that slow tumour progression in mice is reported online in Nature Nanotechnology. Cancer gene silencing RNA delivered using these nanoparticles showed better anti-tumour effects than when delivered using commercially available nanoparticles. This formulation is expected to be an effective gene-delivery system for treating a variety of cancers.

The success of cancer gene therapy relies on effective delivery of small interfering RNA (siRNA) to the specific genes that cause disease, in order to switch them off. Yoshihisa Namiki and colleagues injected magnetic nanoparticles carrying an optimized sequence of siRNA into the bloodstream of mice. They then guided the siRNA-carrying nanoparticles to the tumour using magnets that were either glued on or implanted under the skin near the tumour. The siRNA -- which was designed to silence the expression of a particular gene in the blood vessels of tumours -- reached its destination and stopped the growth of tumour blood vessels after an optimized dose of eight injections. The team showed that tumour growth decreased without any adverse immune reaction or side effects and further analysis confirmed that the gene-silencing effects were due to RNA interference.

The authors believe that this new formulation -- which showed better anti-tumour effects than the magnetic nanoparticles available at present -- could be a robust gene-delivery system for a variety of cancer gene therapy applications.

Author contact:

Yoshihisa Namiki (The Jikei University School of Medicine, Chiba, Japan)
E-mail: cancer_gene_therapy@ybb.ne.jp

Abstract available online.

(C) Nature Nanotechnology.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.