home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

New Genetic Variants Associated with Cancer

 
  August, 13 2009 15:01
your information resource in human molecular genetics
 
     

Common gene variants are associated with increased risk of 3 different types of cancer, according to studies published online in Nature Genetics.

Stephen Chanock and colleagues analyzed the genomes of thousands of pancreatic cancer patients and found that genetic variation at ABO, an important gene that regulates blood type, is associated with increased risk of pancreatic cancer. This finding provides an explanation for studies done in the 1950s and 1960s, which suggested that individuals with the A, AB, or B blood type have increased risk of pancreatic cancer, compared to individuals with blood group O. Pancreatic cancer is a highly fatal disease, leading to mortality in most cases.

Paul Pharoah and colleagues scanned the genomes of thousands of ovarian cancer cases and identified a genetic variant on chromosome 9p22 that is associated with increased risk of this disease. Ovarian cancer also has poor survival rates, with about half of diagnosed cases surviving 5 years past diagnosis.

Finally, Xifeng Wu and her team found that variation in the prostate stem cell antigen (PSCA) gene is associated with increased risk of urinary bladder cancer in US and European populations. Although urinary bladder cancer is more common in Western countries than pancreatic and ovarian cancers, urinary bladder cancer has a better survival rate, with approximately 80% of diagnosed cases surviving past 5 years of diagnosis.

Author contacts:

Stephen Chanock (National Cancer Institute, Bethesda, MD, USA)
E-mail: chanocks@mail.nih.gov

Paul Pharoah (University of Cambridge, UK)
E-mail: paul1@srl.cam.ac.uk

Xifeng Wu (M. D. Anderson Cancer Center, Houston, TX, USA)
E-mail: xwu@mdanderson.org

Abstracts available online:
Abstract of Paper 1.
Abstract of Paper 2.
Abstract of Paper 3.

(C) Nature Genetics press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.