home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Mediator Of Multiple Sclerosis

  August, 27 2009 19:20
your information resource in human molecular genetics

A factor that may contribute to the progressive phase of multiple sclerosis (MS) has been identified in a paper published online in Nature Immunology.

Multiple sclerosis is an autoimmune disease that affects a person's nervous system and leads to physical and cognitive disabilities. There are different patterns of progression for MS with the irreversible progressive phase appearing after the relapsing-remitting phase of the disease. There is currently no effective therapy for the progressive phase of MS.

A group led by Howard Weiner and Francisco Quintana identified a lipid, 15-HC, that is present in elevated concentrations in patients with progressive, but not relapsing-remitting, MS. The scientists found that 15-HC activates a receptor called PARP-1 and that inhibition of PARP-1 activity slows the progression of MS in a mouse model of MS.

Future work will determine whether PARP-1 activity can be manipulated for therapeutic benefit in patients with progressive MS.

Author contacts:

Howard Weiner (Brigham and Women's Hospital, Boston, MA, USA)
E-mail: hweiner@rics.bwh.harvard.edu

Francisco Quintana (Brigham and Women's Hospital, Boston, MA, USA)
E-mail: fquintana@rics.bwh.harvard.edu

Abstract available online.

(C) Nature Immunology.

Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.