home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

New Player in T Cell Maturation

  July, 17 2009 10:07
your information resource in human molecular genetics

Three papers published online in Nature Immunology show that a previously uncharacterized protein called Themis is essential for proper development of T cells. These immune cells are critical for the recognition and elimination of pathogens.

Using distinctly different experimental approaches, teams led by Nicholas Gascoigne, Paul Love, Ronald Schwartz, and Richard Cornall demonstrated that Themis is expressed exclusively in T cells. Each group independently generated and studied Themis-deficient animals, which they found contained few mature and functional T cells.

Adding to the mystery surrounding this unfamiliar protein, the three teams offer somewhat different explanations for how exactly Themis -- which bears little structural resemblance to any other proteins involved in T cell development -- facilitates T cell maturation. Future work is needed to clarify the mechanisms through which Themis influences development of this important immune cell lineage.

Author contacts:

Nicholas R.J. Gascoigne (The Scripps Research Institute, La Jolla, CA, USA)
E-mail: gascoigne@scripps.edu

Paul E. Love (National Institutes of Health, Bethesda, MD, USA)
E-mail: lovep@mail.nih.gov

Ronald H. Schwartz (National Institutes of Health, Bethesda, MD, USA)
E-mail: rschwartz@niaid.nih.gov

Richard Cornall (Oxford University)
E-mail: richard.cornall@ccmp.ox.ac.uk

Abstracts available online:
Paper 1 Abstract.
Paper 2 Abstract.
Paper 3 Abstract.

(C) Nature Immunology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.