home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
 
  HUM-MOLGEN -> Genetic News | search  
 

First Sign Of Trouble

 
  January, 9 2008 23:04
your information resource in human molecular genetics
 
     

Expression of a single stress response protein, even in the absence of 'danger' signals displayed by invading microbes or dying cells, triggers massive reorganization and activation of immune cells, according to a paper published online in Nature Immunology.

Previous studies questioned whether stress response proteins, which are often found on the surfaces of tumours, are sufficient to activate immune defences. Adrian Hayday and co-workers designed a mouse in which expression of the stress response protein Rae1 could be turned on and off in the skin, on demand. Rae1 induction provoked reorganization of skin-resident immune cells and infiltration of activated immune cells from the blood. Surprisingly, some affected skin-resident immune cell populations promoted, whereas others suppressed, tumour rejection.

Future work is needed to understand the mechanism through which Rae1 expression induces such large-scale changes in the skin immune system, and to determine whether manipulation of Rae1 expression might hold therapeutic utility in the treatment of tumours.

Author contact:

Adrian Hayday (King's College London, UK)
E-mail: adrian.hayday@kcl.ac.uk

Abstract available online.

(C) Nature Immunology press release.


Message posted by: Trevor M. D'Souza

print this article mail this article
Bookmark and Share this page (what is this?)

Social bookmarking allows users to save and categorise a personal collection of bookmarks and share them with others. This is different to using your own browser bookmarks which are available using the menus within your web browser.

Use the links below to share this article on the social bookmarking site of your choice.

Read more about social bookmarking at Wikipedia - Social Bookmarking

Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2017 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.