home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Seeing How Viruses Encounter Immune Cells

  January, 24 2008 9:44
your information resource in human molecular genetics
Getting a virus infection often begins by inhaling virus that someone else sneezes out into the air; but where in the body do immune cells come into contact with viruses to initiate effective immune responses? A study in the February 2008 issue of Nature Immunology uncovers a surprising answer that may help to create effective anti-viral vaccines.

A group led by Jon Yewdell use a technique called intravital microscopy, which allows visualization of intact tissues and their cellular constituents, to see where two different types of viruses first encounter immune cells. Focusing on lymph nodes, pea-sized tissues containing different types of immune cells, the group found that rather than encountering immune cells deep within the lymph node, as most previous work has indicated, viruses encounter immune cells just under the lymph node outer capsule. Specialized immune cells called T lymphocytes migrate to this outer region and become activated to trigger antiviral responses.

Pinpointing exactly where in the body immune cells become activated to fight against infecting pathogens, as this new work does, may aid in the design of effective anti-viral vaccines.

Author contact:

Jonathan Yewdell (National Institutes of Health, Bethesda, MD, USA)
Please contact the author through Sitara Maruf, NIAID Office of Communications
E-mail: marufs@niaid.nih.gov

Abstract available online.

(C) Nature Immunology press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2018 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.