home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

Circadian Rhythms

  February, 7 2008 10:04
your information resource in human molecular genetics

The release of blood stem cells into the bloodstream is regulated by circadian rhythms, according to research in in Nature. The work suggests that release of haematopoietic stem cells (HSCs) during an animal's resting period could promote the regeneration of blood stem cell populations and potentially other tissues.

HSCs circulate through the bloodstream and can home into sites throughout the body. Paul Frenette and colleagues show that this traffic is not random but follows a rhythmic pattern. Normal circadian oscillations can be disrupted by changes in the light rhythms, for example after exposure to constant light or a jet lag. Expression of the chemokine CXCL12 in the stem cell niche corresponds to the circadian oscillations; this is a result of adrenergic signals locally delivered by nerves in the bone marrow.

The research demonstrates that the central nervous system can directly regulate the function of a stem cell niche in peripheral tissues. The team also believes that this knowledge could help to increase the yield of HSCs if stem cells are harvested at the right time.


Paul Frenette (Mount Sinai School of Medicine, New York, NY, USA)
E-mail: paul.frenette@mssm.edu

Abstract available online.

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.