Cells that initiate human skin cancer are identified in Nature, and researchers demonstrate how targeting these cells with antibodies can slow the growth of melanomas.
Cancer stem cells have been isolated from a number of human tumours. Here Markus H. Frank and colleagues identify tumour-initiating cells in clinical human malignant melanomas. Tumours with ABCB5+ cells grow faster and spread quicker than those without. Preliminary evidence also suggests that these melanoma stem cells can be specifically targeted with antibodies targeted against ABCB5, which offers a potential therapeutic strategy against melanomas.
Markus H. Frank (Children's Hospital Boston and Brigham & Women's Hospital, Boston, MA, USA)
(C) Nature press release.
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