home   genetic news   bioinformatics   biotechnology   literature   journals   ethics   positions   events   sitemap
  HUM-MOLGEN -> Genetic News | search  

MicroRNAs That Reduce Metastasis

  January, 24 2008 8:50
your information resource in human molecular genetics

Restoring the expression of certain microRNAs (miRNAs) that are lost as breast cancer starts to metastasize suppresses the spread of the cancer, reports a paper in Nature.

Joan Massagué and colleagues identify a set of miRNAs that stop being expressed as human breast cancer cells develop metastatic potential. They then demonstrate that restoring the expression of this miRNA set in malignant cells suppresses lung and bone metastasis.

One in particular, miR-126, reduces overall tumour growth when restored, and another, miR-335, regulates a set of genes that increase the risk of metastasis. The association with metastatic relapse suggests that these molecules could be used in better prognosis for patients.


Joan Massagué (Memorial Sloan-Kettering Cancer Center/Howard Hughes Medical Institute, New York, NY, USA)
E-mail: massaguj@mskcc.org

(C) Nature press release.

Message posted by: Trevor M. D'Souza

print this article mail this article
Latest News
Variants Associated with Pediatric Allergic Disorder

Mutations in PHF6 Found in T-Cell Leukemia

Genetic Risk Variant for Urinary Bladder Cancer

Antibody Has Therapeutic Effect on Mice with ALS

Regulating P53 Activity in Cancer Cells

Anti-RNA Therapy Counters Breast Cancer Spread

Mitochondrial DNA Diversity

The Power of RNA Sequencing

‘Pro-Ageing' Therapy for Cancer?

Niche Genetics Influence Leukaemia

Molecular Biology: Clinical Promise for RNA Interference

Chemoprevention Cocktail for Colon Cancer

more news ...

Generated by News Editor 2.0 by Kai Garlipp
WWW: Kai Garlipp, Frank S. Zollmann.
7.0 © 1995-2023 HUM-MOLGEN. All rights reserved. Liability, Copyright and Imprint.