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Deletions on chromosome 5q are associated with certain blood-cell-production diseases and in Nature researchers identify a candidate tumour suppressor gene for these.
Using an RNA-interference-based approach to identify haploinsufficient tumour suppressor genes, Todd R. Golub and colleagues identify a molecule called RPS14. It usually acts as a regulator of ribosomal RNA processing and the research adds to the growing list of ribosomal factors that are linked to tumour suppression when they are not expressed properly. Forced expression of RPS14 in patient-derived bone marrow cells rescued the disease phenotype. The research demonstrates that RNAi screening is an effective strategy for identifying genes for haploinsufficient disorders ? which occur when only a single copy of a gene is functional. CONTACT Todd R. Golub (Broad Institute of Harvard and MIT, Cambridge, MA, USA)
E-mail: golub@broad.harvard.edu (C) Nature press release.
Message posted by: Trevor M. D'Souza
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