To develop optimal vaccines for clinical applications it is vital to understand the mechanisms of their actions, and research in Nature demonstrates how DNA vaccines may induce adaptive immune responses.
DNA vaccines induce adaptive immune responses, mainly through induction of type I interferons. Ken Ishii and colleagues use mice to show that this occurs by a mechanism that is independent of the activation of nucleic-acid-binding Toll-like receptors. Instead, some T-cell responses require activation of the TANK-binding kinase 1 (TBK1)-mediated innate immune signalling pathway in haematopoietic cells. In non-haematopoietic cells, TBK1 is critical for the activation of CD8 T cells. Therefore, in two distinct cellular mechanisms, TBK1 is a key player in DNA-vaccine-induced immunity.
Ken Ishii (Osaka University, Japan)
(C) Nature press release.
Message posted by: Trevor M. D'Souza